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Posts Tagged ‘neurodegenerative disease patents

An open access database of biomarker and drug discovery assays/protocols  for neurodegenerative diseases. The listed protocols are extracted from and linked to patents and journal articles.  The innovative representation of protocols in this database will be a useful  tool for idea/concept generation for developing innovative approaches for Alzheimer’s disease and Parkinson’s disease biomarker and drug discovery research. Please follow this link to see the complete list of protocols: http://www.sciclips.com/sciclips/bio-protocols.do?catName=Neurodegenerative%20disease%20biomarker%20and%20drug%20discovery

Related tools:

1. Bioprotocols
2. Comprehensive cancer biomarker database with companion diagnostics pathway
4. Biomarker news


Highlights of recent drug discovery patents (US issued and applications):

Neurological and neurodegenerative disease patents

1. Activators of Rho GTPases for the treatment of cognitive and learning disorders
2. N-acetyl-D-mannosamine for the treatment of brain hypofunction
3. Protein cross-linking inhibitor for the treatment of neurodegenerative diseases
4. New PDE9A inhibitors for the treatment of Alzheimer’s disease
5. Proteosome-based adjuvant for the treatment of cerebral amyloid angiopathy

Cardiovascular disease drug discovery patents

1. Thrombin-activatable fibrinolysis inhibitor (TAFI) as drug target for treating thrombosis
2. Angiotensin-II-receptor blocker-HMG-CoA reductase inhibitor combination therapy for treating hypertension
3. Dronedarone to reduce cardiovascular hospitalizations and mortality
4. Novel platelet ADP receptor inhibitors for the treatment of thrombosis
5. Adenosine A2A receptor as a drug target for the treatment of atrial fibrillation
6. Novel synthetic hexadecasaccharides for the treatment of thrombosis

Anti-cancer drug discovery patents

1. Inhibitors of t-RNA and 28s rRNA for the treatment of chronic lymphocytic leukemia (CLL)
2. Compounds that inhibits expression of iNOS and COX-2 without inhibiting NF-kappa B
3. Small molecule choline kinase inhibitors for the treatment of cancer
4. Matrix metalloproteinase derived peptides for the treatment of melanoma and breast cancer
5. siRNA targeting heterogeneous nuclear ribonucleoprotein K expression for the treatment of cancer
6. Mitochondria targeted rosamine derivatives for the treatment of cancer
7. Combination of ZD6474 and pemetrexed for the treatment of solid tumors
8. Combination of P70S6 kinase inhibitor and mTOR inhibitor for the treatment of cancer
9. siRNA targeting the CYCLIN D1/TROP2 chimeric mRNA for the treatment of cancer
10. Nanoparticles for the enhancement of radiotherapy efficacy in cancer patients
11. Cancer vaccine formulation using PASD1-derived peptides

Drug delivery patents

1. Enhanced topical delivery of siRNA
2. Iontophoretic patch for the treatment of migrane
3. Magnetic nanodelivery of therapeutic agents across the blood brain barrier for the treatment of CNS disorders

Herbal drug patents

1. Brazilin for the treatment of allergic diseases and allergic asthma
2. Herbal extract with liver-X-receptor modulators for the treatment of obesity

Obesity drug patents

1. Lipoprotein lipase as a drug target of obesity
2. Enterostatin for the treatment of obesity
3. Small molecule ghrelin O-acyltransferase (GOAT) inhibitors for the treatment of obesity

Combination therapy patents

1. Combination therapy for treating female sexual dysfunction
2. Combination therapy for treating migraine
3. Combination therapy for intervertebral disc (IVD) degeneration
4. Combination of ZD6474 and pemetrexed for the treatment of solid tumors
5. Combination of P70S6 kinase inhibitor and mTOR inhibitor for the treatment of cancer

Other diseases

1. N-formyl-methionyl peptides for treating inflammation
2. Method for optimizing methylphenidate treatment in attention deficit hyperactivity disorder (ADHD) patients
3. Treating sensorineural hearing loss using donepezil hydrochloride
4. Guanylate cyclase receptor peptide agonists for the treatment of inflammatory diseases
5. WNT3A for the treatment of scarring
6. A method of treating fibromyalgia using acetyl L-carnitine
7. A compound for treating spasticity
8. Method for reducing CNS and gastrointestinal side effects associated with long term dextromethorphan/quinidine combination therapy
9. siRNA targeting HIF alpha for the treatment of age-related macular degeneration
10. ADFP as a drug target for the treatment of acne, seborrhoeic dermatitis and skin disorders associated with hyperseborrhoea
11. Antisense oligonucleotides targeting Smad3 for treating fibrosis and scarring
12. Toll-like receptor 4-signaling activity via CD14 as a drug target for treating rabies virus or vesicular stomatitis virus infections
13. Toll-like receptor 4-signaling activity via CD14 as a drug target for treating autoimmune diseases
14. Nanoparticle biosensor for measuring protease activity

Details:


Comprehensive Cancer Bomarker Database

Sciclips consultancy

Diagnostic & Prognostic Biomarker Database

Bioprotocol database (open access)

Combination therapy database (open access)

Therapeutic drug target database (open access)

Bioinformatics databases (open access)

Stem cell researchers database

A comprehensive database for stem cell researchers, Stem cell research reagents, Stem cell patents, Stem cell grants, Stem cell clinical trials, Stem cell statistics, Stem cell news and Stem cell open innovation ideas. Please visit http://www.sciclips.com/

Sciclips consultancy

Proteomics researchers database

A comprehensive database for proteomics researchers, Proteomics research reagents, Proteomics patents, Proteomics grants, Proteomics clinical trials, Proteomics statistics, Proteomics news and Proteomics open innovation ideas. Please visit http://www.sciclips.com/

Share or sell research reagents prepared in your laboratory

Drug target database (open access)

Pharmacogenomics protocols online

Proteomics and Mass spectrometry (MS) protocols online

Therapeutic drug targets database (open access)

Drug discovery, Biopharmaceuticals, HTS assays protocols online

Protein display/Protein engineering/Directed evolution protocols online

Molecular biology and Cell biology protocols online

siRNA protocols miRNA protocols online

Video protocols

Cell culture video protocols, Cytotoxicity assay video protocols, Stem cell video protocols, Molecular biology video protocols http://www.sciclips.com/sciclips/video-protocols.do

Sciclips consultancy

Sciclips

Bioprotocols online (open access)

Combination therapy database (open access)

Therapeutic drug targets database (open access)

Bioinformatics databases (open access)

HTS assay protocols online (open access)

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