Sciclips's Blog

Archive for July 2011


Drug discovery

1. Induced pluripotent stem cell based human cellular model for Rett syndrome
2. Water drinking could assist overweight children in weight loss
3. Organic cation transporter 2 (OCT2) as potential pharmacological target for mood disorders therapy
4. HDAC6 inhibitors for the treatment of Charcot-Marie-Tooth disease
5. Protein complementation with resonance energy transfer to study conformational changes in response to activation of a GPCR heteromer
6. STAT3 pathway as a therapeutic drug target of prostate cancer stem cells
7. A prodrug approach for improving tuberculosis drug targets
8. Novel thalidomide derivatives for the treatment of sickle cell diseases
9. Novel isoniazid derivatives for the treatment of tuberculosis
10. iPS cells derived neural stem cells for glioma gene therapy
11. Identification galactose-1-phosphate uridyltransferase (GALT) inhibitors for classic galactosemia treatment
12. Potent inhibitors of dihydroorotate dehydrogenase (DHODH) for the treatment of malaria
13. Promising reversible and selective MAO-B inhibitors identified
14. A screening strategy to identify drugs that suppress statin muscle toxicity
15. Fluorescent sensors to study cell signaling molecules with high spatial and temporal resolution
16. Anti-progastrin antibody for the treatment of breast cancer and colorectal cancer
17. Plasminogen activator inhibitor-1derived peptides for the treatment of asthma
18. Parstatin peptide for the treatment of myocardial ischemic injury
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do


Biomarkers

1. Multidrug resistance (MDR) gene signatures as prognostic biomarkers of ovarian cancer
2. Urinary metabolomic biomarkers of broccoli and Brussels sprouts consumption
3. Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools
4. Proteins associated with aggressive prostate cancer identified
5. Urinary NGAL a promising early marker for monitoring renal impairment in patients with short-term type 2 diabetes
6. Novel glycan biomarkers of colon cancer
7. REGIV as a biomarker of peritoneal recurrence after curative resection in gastric cancer patients
8. Biomarker panel for the diagnosis of live injury
9. kPCR assay for the detection of KRAS and PIK3CA mutations in colorectal cancer
10. Urinary metabolomic biomarkers for the diagnosis of prostate cancer
11. In vivo imaging of ADLH in cancer stem cells
12. EML4-ALK gene or protein fusion as a biomarker for the diagnosis of non-small cell lung cancer
13. Progastrin as a biomarker for the diagnosis of breast cancer
14. Progastrin as a biomarker for the diagnosis of liver cancer, cirrhosis, and hepatitis C
15. MAGEC2- a biomarker for the differential diagnosis of testicular germ cell tumors
16. PRDM1 protein a potential biomarker of radiation therapy–induced secondary malignancies in pediatric Hodgkin’s lymphoma
17. Genetic variations in chromosome 11 to predict schizophrenia risk
18. GRP78 SNP as a predictive biomarker of liver cirrhosis in persistent HBV carriers
Details:

1. Human chorionic gonadotropin (hCG) based cancer vaccine
2. Stable insulin formulation
3. Naltrexone for weight loss therapy in patients suffering from major depression
4. Method for treating hormone ablative therapy induced osteoporosis in breast cancer patients
5. Statin and vitamin D combination for the treatment of migraine headaches
6. Angiopoietin-like 3 as a therapeutic drug target of cardiovascular and metabolic diseases
7. Combination therapy for obstructive sleep apnea syndrome
8. FAAH inhibitors to treat Parkinson’s disease and restless legs syndrome
9. METAP-2 inhibitors for treating benign prostate hyperplasia
10. miR-224 and Ubc9 as breast cancer drug targets
11. Novel mGlu2 agonists for the treatment of bipolar disorder, schizophrenia, depression, and generalized anxiety disorder

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

1.Breath biomarkers for the diagnosis of breast cancer, colon cancer, head and neck cancer and prostate cancer
2. Calcineurin polymorphism as biomarker for the diagnosis of schizophrenia
3. MicroRNA (miRNA) biomarkers for the diagnosis of stage 1 non-small cell lung cancer
4. VEGF, CGSF, MIG, RANTES, IL-2, IL-3 and MDC as lung cancer serum biomarkers
5. Serum secretory phospholipase A2-IIA as biomarker for the diagnosis of prostate cancer or lung cancer
6. Exosomel biomarkers for the diagnosis of cardiovascular diseases
7. JC virus antibodies as biomarker for identifying the risk of developing progressive multifocal leukoencephalopathy (PML)
8. CD44 polymorphism as biomarkers for tumor recurrence in gastric cancer patients
9. Gene expression biomarkers for determining the clinical outcome in renal cell cancer patients

Details:

1. mRNA biomarkers for the diagnosis of thyroid cancer
2. Metabolomic biomarkers for the diagnosis of preeclampsia
3. Endogenous metabolites for the diagnosis of sepsis
4. Nine-gene classifier biomarkers for the diagnosis of chronic obstructive pulmonary disease (COPD)
5. HLDGC gene/protein as a diagnostic biomarker of hair-loss disorder (Alopecia)
6. Anti-factor IX activating catalytic antibody as a prognostic biomarker of hemophilia
7. TOMM40 SNP is associated with increased risk of Alzheimer’s disease
8. Predictive biomarkers of dasatinib treatment in colon cancer patients
9. A portable mass spectrometry
10. Calmodulin protein methyltransferase for the diagnosis of atypical hypotonia-cystinuria syndrome

Details:

1. Multiprotein cancer vaccine
2. Autologous cancer vaccine
3. Cilastatin for decreasing the nephrotoxic effects of drugs without reducing their therapeutic effects
4. siRNA for the treatment of glioblastoma multiforme
5. TOMM40 gene SNP rs10524523 as a drug target for Alzheimer’s disease
6. Non-lipidated forms of the HpaA protein as a vaccine target for H. pylori infection
7. DNA vaccines against chikungunya virus
8. Combination therapy using ciglitazone and cisplatin enhances the inhibition of growth of ovarian cancer
9. Novel selective estrogen receptor modulators for the treatment of osteoarthritis
10. Betahistine for treating Eustachian tube dysfunction such as vertigo
11. Lyophilized DNA formulations for the treatment of coronary (CAD) or peripheral artery disease (PAD)
12. siRNA mediated inhibition of thrombospondin-1 (TSP-1) for the treatment of cancer
13. Oligonucleotide decoys for the treatment of pain
Stem cells cultured in the presence of HS-2 for the treatment of bone fracture
14. Compounds for differentiation of pluripotent stem cells into insulin producing cells
15. Improved cardiomyogenic differentiation of pluripotent cells with an inhibitor of deltaNp63 expression
16. Antimalarial drug, artemisinin, for the treatment of herpes viral infections
17. A2A adenosine receptor agonists for treating recurrent tumor metastases following liver resection
18. Leukotriene receptor antagonists for the treatment of snoring and sleep apnea
19. Glucosylceramide synthase inhibitors for the treatment of collapsing glomerulopathy and other glomerular diseases
20. Generation of pancreatic hormone-expressing cells limbal stem cells
21. Method for identifying Plasmodium strains that causes severe malaria

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do


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