Sciclips's Blog

Recent Drug Discovery and Biomarker Research Highlights

Posted on: August 23, 2011


Drug discovery

1. Brain arachidonic acid cascade enzymes as therapeutic drug target for the treatment of Alzheimer’s disease
2. A real-time thallium flux HTS assay of human potassium channel opener
3. A simple assay for screening of protein kinase inhibitors in cell lysates
4. A label-free high-throughput mass spectrometry assay for rapidly screening epigenetic targets
5. A mutation in the human proteasome is associated with Nakajo-Nishimura syndrome
6. A spectrophotometric assay for conjugation of ubiquitin and ubiquitin-like proteins
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do


Biomarkers
1. Protein chip for diagnosis of sepsis
2. c-myb alternative splicing variants as potential biomarkers of leukemia
3. Biomarkers for the diagnosis of anorchia
4. Biomarkers for assessing therapeutic efficacy in patients with Hutchinson-Gilford progeria syndrome
5. IGF-1 as a biomarker of abdominal aortic aneurysms
6. Serum N-glycans as colorectal cancer biomarkers
7. Gene markers associated with NEO personality traits
8. Human intelligence is highly heritable and polygenic
9. Mannose 6-phosphate as a biomarker for the diagnosis of mucolipidosis Type II
10. ME-2 antigen as a biomarker for the diagnosis of endometriosis
11. Uromodulin and Kinins as biomarkers for the diagnosis of chronic allograft dysfunction
12. Micronucleus as a biomarker to screen women who are at risk of developing cervical cancer
13. Biomarkers of neuronal ceroid lipofuscinosis
14. Biomarkers to identify CKD patients in whom sodium targeting can improve blood pressure and proteinuria
15. Mitochondrial DNA copy number as a possible biomarker of pancreatic cancer
16. Biomarkers associated with higher risk of progression in lacunar strokes
17. XRCC1 SNP biomarker to predict genetic susceptibility for papillary thyroid carcinoma
18. HESRG as a specific biomarker for intracranial germinoma and embryonal carcinoma
19. Predictive biomarkers of efavirenz-based HAART-induced liver injury in HIV patients
20. Biomarker for predicting the development of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

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