Sciclips's Blog

Recent Drug Discovery Patent Highlights

Posted on: August 29, 2011


Highlights of the drug discovery patent applications (US) published on August 25, 2011:

1. Tetrazole compounds as uric acid transporter 1 (URAT1) inhibitors for the treatment of gout
2. Modified lecithin-cholesterol acyltransferase (LCAT) for the treatment of atherosclerosis
3. SPINK1 as a clinical target for prostate cancer
4. Serine threonine kinase inhibitors for treating hormone-refractory prostate cancer
5. Cyclic depsipeptide from chromobacterium for treating chronic obstructive pulmonary disease (COPD) or asthma
6. Novel P2X3 receptor antagonists for the treatment of pain
7. Composite hydroxide of a hydrotalcite and an aluminum hydroxide for the treatment of gastric ulcer
8. Novel herbal composition for the treatment of male sexual dysfunction
9. RNA aptamers as selective inhibitors of emergence of the selected miRNAs
10. Multiple myeloma SET domain-containing protein (MMSET) as a drug target for the treatment of cancer
11. Vitamin D3 lactam derivatives for the treatment of Paget’s disease
12. Calcium leakage inhibitory peptides derived from ryanodine receptor for the treatment of heart failure
13. Combination of a nitric oxide-cobalamin complex and cobalamin drug conjugate for the treatment of cancer
14. A1 adenosine receptor as a therapeutic drug target for the treatment of hearing loss
15. Thrombomodulin variants for the treatment of acute kidney injury
16. Inhibitors of VEGF-Axxx binding to VEGFR-2 for the treatment of age-related macular degeneration
17. Nanoparticle based oral formulations of chemotherapeutic agent
18. 4-O-methylhonokiol for the treatment of Alzheimer’s disease
19. Novel tetrahydronaphthalene compounds as potent calcium channel blockers
20. A novel combination therapy approach to breast cancer treatment
21. N1 -benzo[1,3]dioxol-5-ylmethyl-N2-substituted biguanide derivative for the treatment of diabetes
22. Homoisoflavanone for the treatment of inflammatory diseases or allergic diseases
23. Herbal based dual cyclooxygenase and lipoxygenase inhibitors for the treatment of skin diseases
24. Combination of DNA methyltransferase inhibitor and sapacitabine for the treatment of cancer
25. Oral composition of taxane for the treatment of cancer
26. Adenine nucleotide translocator 2 (ANT2) gene as a breast cancer stem cell drug target
27. Adenine nucleotide translocator 2 gene targeted siRNA or shRNA for the treatment of breast cancer
28. Combination therapy with niacin and 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor for the treatment of atherosclerosis
29. Myeloperoxidase (MPO) inhibitors for the treatment of multiple system atrophy and Huntington’s disease
30. Combination of P70S6 kinase inhibitor and EGFR inhibitor for the treatment of non-small cell lung cancer
31. c-Src inhibitors for the treatment of sudden cardiac death
32. Annelated pyrrolidin sulfonamides with oxadiazolone headgroup as PPARdelta or PPARdelta and PPARalpha agonists
33. Combination therapy using pitavastatin for preventing rupture of a lipid rich plaque in an atherosclerotic lesion
34. Pyrimidine derivatives, as gamma secretase modulators, for the treatment of Alzheimer’s disease
35. Novel 4-(indazolyl)-1,4-dihydropyridine derivatives as protein tyrosine kinase inhibitors
36. Combination therapy for chronic obstructive pulmonary disease and asthma
37. Quinolin-4-one and 4-oxodihydrocinnoline derivatives PARP inhibitors
38. Smad7 specific inhibitors for the treatment of CNS diseases
39. Substituted bicyclic amines as antagonists of the somatostatin receptor subtype 5 (SSTR5)
40. Combination of anti-epileptic drug and a psychostimulant for the treatment of psychiatric disorders
41. Immunotherapy for the treatment of Multiple Sclerosis
42. Wntl-Lmxla signaling pathway as a drug target for treating Parkinson’s disease
43. TGF-beta1 as a drug target for treatment of corneal fibrosis and corneal

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