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Archive for September 2011

Highlights of US patent applications published on Sept. 22, 2011

1. Biomarkers for prognosing responsiveness to anti-TNF alpha therapy in patients with inflammatory bowel disease
2. Urinary biomarker for the diagnosis of polycystic kidney disease
3. Syngap1 as a biomarker for the diagnosis of mental retardation
4. Molecular diagnostic method for the detection of Turner Syndrome
5. Phosphorylated Beclin-1 as a biomarker for the diagnosis Alzheimer’s disease, Huntington’s disease and Parkinson’s disease
6. Azurophilic granule proteases as markers in cardiological diseases
7. SNP biomarkers for determining increased susceptibility to thyroid cancer
8. Biomarker for accurate diagnosis of cystic fibrosis (CF)
9. Biomarker for determining an increased risk for side effects of selective serotonin reuptake inhibitor (SSRI) treatment
10. Predictive biomarkers of clinical response to glatiramer acetate therapy in multiple sclerosis
11. ELISPOT assay for early detection of antigen exposure
12. Biomarkers for predicting the recurrence, progression, and metastatic potential of a prostate cancer


Highlights of US patent applications published on Sept. 22, 2011:

Diseases: Multiple sclerosis, obesity, atherosclerosis ,diabetes mellitus, influenza, cancer, prostate cancer, cystic fibrosis, hyperparathyroidism, atherosclerosis, myeloma, leukemia, lymphoma, Alzheimer’s disease, Huntington’s disease, anxiety, mood disorder, depression, hypertension, type 2 diabetes, HPV infection, pain, rheumatoid arthritis, ulcerative colitis, restenosis, epilepsy and malaria

1. Fc-gamma receptor for treating multiple sclerosis
2. Combination therapy for influenza
3. Type 5 adenylyl cyclase (AC5) inhibitors for treating obesity, atherosclerosis and diabetes mellitus
4. Novel G-protein coupled receptor 43 (GPR43) agonists for treating metabolic disorders
5. GPR119 agonists for therapeutic treatment of diabetes and obesity
6. Combination therapy for diabetes
7. Phosphate transporter activity inhibitors as drug targets of non-viral epithelial damage
8. Autotaxin inhibitors for treating cancer
9. CLK kinases as new kinase targets of tetrabromobenzimidazoles for treating cancer
10. Saponin extract for treating cancer
11. ANT4 as drug target for treating cancers
12. Benzenesulfonamide derivative as a cell cycle inhibitor for treating solid tumors
13. BTLA-HVEM protein interaction as s a drug for the treatment of cancer and autoimmune diseases
14. A novel cyclobutyl purine derivative for the treatment of cancer
15. Novel derivatives of tetrabromobenzimidazole as Pim kinase family inhibitors for treating cancer
16. Bifunctional antiandrogen for treating prostate cancer
17. Inhibitors of Hec1/Nek2 interaction for treating cancer
18. HSP90 inhibitor compounds for treating cancer
19. Novel manassantin compounds inhibiting HIF-1 for the treatment of cancer
20. Cyclopamine analogs for treating myeloma, leukemia or lymphoma
21. Inhibitors of phosphoinositide dependent kinase 1 (PDK1) for treating cancer
22. Combination of Hsp90 inhibitor and an mTOR inhibitor for treating cancer
23. GLP-1 agonists for treating an early cardiac or early cardiovascular disease
24. Kynurenine-3-monooxygenase (KMO) as therapeutic drug target of Huntington’s disease
25. Platelet-activating factor (PAF) analogs for treating inflammatory diseases
26. Novel pyrrolopyrazine derivatives as JAK3 inhibitors for treating autoimmune and inflammatory diseases
27. Dual acting MMP-2 and MMP-9 inhibitors for treating pain
28 Novel pyrazolyl-pyrimidine derivatives as potassium channel modulating agents
29. Pyridine and pyrazine derivative for the treatment of cystic fibrosis
30. Novel modulators of the nicotinic acetylcholine receptors
31. Heteroaryl-substituted piperidinyl urea compounds as FAAH inhibitors
32. Fatty acid amide hydrolase (FAAH) inhibitors for treating rheumatoid arthritis and pain
33. Serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor compounds for treating pain disorder
34. Platelet activating factor (PAF) receptor antagonist for treating atherosclerosis
35. Biologically active amide ligands of NPY Y5 receptor treating cognitive disorders
36. Combination therapy for Parkinson’s disease
37. Combination therapy for epilepsy
38. Dihydroquinazoline inhibitors of BACE1 for treating Alzheimer’s disease
39. Treatment of pain with opioid analgesic dosage forms which are less subject to abuse
40. Prodrug compound of a rapamycin analog for treating restenosis
41. CCR1 antagonists for treating inflammatory diseases
42. Novel calcium receptor modulating agents for treating hyperparathyroidism
43. Oxadiazoles fused heterocyclic derivatives as selective S1P1 agonists for treating multiple sclerosis
44. Stable solid forms of modulators of CFTR for treating cystic fibrosis
45. Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases
46. Pyrazole compounds as CCR1 antagonists for treating rheumatoid arthritis and multiple sclerosis
47. New imidazolidinedione derivatives for treating malaria
48. Modulators of store-operated calcium channels for the treatment of multiple sclerosis, rheumatoid arthritis and ulcerative colitis
49. dsRNA inhibiting the expression of a human E6AP gene for treating HPV infection
50. Combination therapy for pain
51. Novel N-heteroaryl-benzamides as glucokinase activators for treating type 2 diabetes
52. Inhibitors of AraC-XylS family and MarA family transcription factors as antibacterial drug targets
53. Dual-acting compounds for treating hypertension
54. Heterocyclic compounds as mGluR5 antagonists for treating anxiety, mood disorder, and depression
55. Novel caspase-6/-3 inhibitors for treating Huntington’s disease
56. Epothilone D for treating Alzheimer’s disease
57. Inhibitors of the mitotic kinesin KSP for the treatment of various diseases
58. Thiol derivative of ethyl mercury is thimerosal for treating viral infections
59. ANT4 as drug target for inducing contraception in a male
60. Carnitine palmitoyl transferase 1 (CPT1) enzyme inhibitors for the treatment of various diseases


Highlights of recent stem cell patents issued on Sept.20, 2011 (US patents) and patent applications published on Sept.15, 2011 (US and WO (PCT)).

1. Stem cell matrix dressing for rapid repairing or healing of skin damage
2. Prohibitin as a biomarker for identifying undifferentiated pluripotent stem cells
3. Recombinant laminin-10 for enhancing self-renewal of pluripotent human stem cells
4. Stem cells for treating hemorrhagic shock
5. Method for the enrichent of cardiac stem cells
6. Marker for determining the susceptibility of a cancer patient to an osteoblastic response in mesenchymal stem cells
7. Stem cell mobilization for the treatment of damaged myocardium
8. Method of inducing the differentiation of germline stem cells
9. Stem cells derived from monocytes for treating tissue damage
10. Method for differentiating retinal stem cells into neural retinal cells
11. Stem cell therapy to build a bypass tract in the heart
12. Dermal papilla tissues having hair follicle inducting ability from stem cells
13. Adipose stem cell culture derived supernatant for the treatment of neural death
14. Treating radiation damage using genetically modified mesenchymal stem cells
15. Anti-apoptotic protein STC-1 expressing stem cells for the treatment of prostate cancer
16. Treating leukemia using PTH/PTHrP receptor antagonists that increase the normal hematopoietic stem cells
17. Method for isolating breast cancer stem cells
18. Enhanced proliferation and differentiation of stem cells using polyanion cocktail
19. SDF-1 mediated enhanced proliferation and survival of mesenchymal precursor cells
20. Method for inducing differentiation from retinal progenitor cells into retinal cells
21. Stem cells for treating brain or spinal cord injury
22. Stem cell binding peptide containing implantable devices for tissue repair


Highlights of recent US patent applications, excluding cancer patents, published on September 15, 2011:

1. GABA receptor as a drug target for treating a central nervous system (CNS) injury
2. Inositol and trehalose derivatives for treating Alzheimer’s disease and Huntington’s disease
3. CI-994 or dinaline for treating memory/cognition and anxiety disorders
4. HMGB1 as drug a target for treating necrotizing enterocolitis
5. Potassium 2-(1-hydroxypentyl)-benzoate (PHPB) for treating senile dementia
6. Novel cinamic compounds as histone deacetylase (HDAC) inhibitor
7. Antisense oligonucleotide based modulators of nuclear hormone receptors for the treatment of inflammation
8. Antisense oligonucleotide targeting PCSK9 for the treatment of hypercholesterolemia
9. MicroRNAs as drug target for the treatment of anorexia
10. MicroRNAs associated with PEPCK-c mRNA expression as a drug target for the treatment of diabetes
11. Modulators of peroxisome proliferator activated receptor gamma (PPARgamma) for the treatment of autosomal dominant polycystic kidney disease
12. Prostacyclin (PGI2) receptor as a drug target for the treatment of pulmonary arterial hypertension (PAH)
13. Therapeutic imprinting for the treatment of psychiatric disorders
14. Azaisoquinolinone derivatives as potent NK3 antagonists for the treatment of psychosis
15. Treating seizures and epilepsy by administering huperzine directly to the central nervous system (CNS) tissue
16. Frizzled 2 (FZD2) as a drug target for the treatment of treatment of alopecia
17. Orally administered small molecule c-Mpl agonist for the treatment of thrombocytopenia
18. Alpha adrenergic receptor agonists for treating acute erythema
19. Alpha adrenergic receptor agonists for reducing post-surgical bleeding
20. A novel therapeutic agent for treating age-related macular degeneration or retinitis pigmentosa
21. Hyaluronic acid tetrasaccharide for the treatment of ulcer or hepatopathy
22. Treating various human diseases by activating mitochondria using chitooligosaccharide
23. Glycosilated long pentraxin 3 (PTX3) for treating influenza virus and respiratory syncytial virus infections
24. Protease-resistant mutants of stromal cell derived factor-1 (SDF-1) for treating tissue damage
25. Human chorionic gonadotropin (hCG) for the treatment of mood disorders and alcoholism
26. Cellobiose compounds from herbal extracts for cancer therapy

Highlights of recent US patent applications published on September 15, 2011:

1. Anti-KAAG1 monoclonal antibodies for the treatment of ovarian cancer
2.Novel inhibitors of cdc25 phosphatases for the treatment of cancer
3. Double stranded iRNA mediated inhibition of VEGF
4. Alpha-fetoprotein (AFP) antibodies for treating hepatocellular carcinoma and germ cell tumors
5. MicroRNA, miR-101, as a target for cancer therapy
6. Treating radiation damage using genetically modified mesenchymal stem cells
7. Novel compounds that inhibit MDM2-p53 interaction for the treatment of cancer
8. Allopurinol for the treatment or prevention of chemotherapy-induced palmar plantar erythrodysesthesia (PPE)
9. Cyclin-dependent kinase (CDK) inhibitors to reduce the cytotoxicity of chemotherapeutic compounds in cancer patients
10. Cyclin-dependent kinase (CDK) inhibitors to reduce the side effects of radiation therapy in cancer patients
11. A method for optimizing treatment of chronic myeloid leukemia (CML) with imatinib mesylate
12. Bidesmosidic betulin and betulinic acid saponin derivatives for the treatment of lung, colorectal, breast and prostate cancers
13. Polymer micelle composition for the treatment of resistant cancers
14. Combination of pterostilbene and quercetin for the treatment of melanoma
15. Orally bioavailable compounds for treating cancer
16. TRIM71 as a therapeutic drug target of ovarian, lung and kidney cancers
17. MicroRNAs as therapeutic drug targets for the treatment of malignant peripheral nerve sheath tumors (MPNST)
18. PTH/PTHrP receptors as therapeutic drug target for the treatment of leukemia
19. Treating hormone refractory prostate cancer using compounds that increase in intracellular granularity of cancer cells
20. Combination of EGFR tyrosine kinase inhibitor and curcumin for treating non-small cell lung cancer
21. Thrombin inhibitors for treating a prevascularized metastasized tumor


Highlights of recent US patent applications published on September 15, 2011:

1. Combination of pterostilbene and quercetin for the treatment of melanoma
2. Combination therapy for obstructive sleep apnea syndrome
3. Combination therapy for erectile dysfunction
4. Combination therapy for Cushing’s syndrome or adrenal incidentaloma
5. Combination therapy for asthma or chronic obstructive pulmonary disease (COPD)
6. Combination therapy for hyperlipidemia and subcutaneous fat loss associated with anti-retroviral treatment in HIV-1 patients
7. Combination of EGFR tyrosine kinase inhibitor and curcumin for treating non-small cell lung cancer
8. Combination therapy for Duchenne muscular dystrophy
9. Combination of S1P receptor agonist and JAK3 kinase inhibitor for the treatment of autoimmune diseases
10. Combination therapy for treating pulmonary hypertension

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