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Recent US Patent Applications in Drug Discovery

Posted on: September 26, 2011


Highlights of US patent applications published on Sept. 22, 2011:

Diseases: Multiple sclerosis, obesity, atherosclerosis ,diabetes mellitus, influenza, cancer, prostate cancer, cystic fibrosis, hyperparathyroidism, atherosclerosis, myeloma, leukemia, lymphoma, Alzheimer’s disease, Huntington’s disease, anxiety, mood disorder, depression, hypertension, type 2 diabetes, HPV infection, pain, rheumatoid arthritis, ulcerative colitis, restenosis, epilepsy and malaria

1. Fc-gamma receptor for treating multiple sclerosis
2. Combination therapy for influenza
3. Type 5 adenylyl cyclase (AC5) inhibitors for treating obesity, atherosclerosis and diabetes mellitus
4. Novel G-protein coupled receptor 43 (GPR43) agonists for treating metabolic disorders
5. GPR119 agonists for therapeutic treatment of diabetes and obesity
6. Combination therapy for diabetes
7. Phosphate transporter activity inhibitors as drug targets of non-viral epithelial damage
8. Autotaxin inhibitors for treating cancer
9. CLK kinases as new kinase targets of tetrabromobenzimidazoles for treating cancer
10. Saponin extract for treating cancer
11. ANT4 as drug target for treating cancers
12. Benzenesulfonamide derivative as a cell cycle inhibitor for treating solid tumors
13. BTLA-HVEM protein interaction as s a drug for the treatment of cancer and autoimmune diseases
14. A novel cyclobutyl purine derivative for the treatment of cancer
15. Novel derivatives of tetrabromobenzimidazole as Pim kinase family inhibitors for treating cancer
16. Bifunctional antiandrogen for treating prostate cancer
17. Inhibitors of Hec1/Nek2 interaction for treating cancer
18. HSP90 inhibitor compounds for treating cancer
19. Novel manassantin compounds inhibiting HIF-1 for the treatment of cancer
20. Cyclopamine analogs for treating myeloma, leukemia or lymphoma
21. Inhibitors of phosphoinositide dependent kinase 1 (PDK1) for treating cancer
22. Combination of Hsp90 inhibitor and an mTOR inhibitor for treating cancer
23. GLP-1 agonists for treating an early cardiac or early cardiovascular disease
24. Kynurenine-3-monooxygenase (KMO) as therapeutic drug target of Huntington’s disease
25. Platelet-activating factor (PAF) analogs for treating inflammatory diseases
26. Novel pyrrolopyrazine derivatives as JAK3 inhibitors for treating autoimmune and inflammatory diseases
27. Dual acting MMP-2 and MMP-9 inhibitors for treating pain
28 Novel pyrazolyl-pyrimidine derivatives as potassium channel modulating agents
29. Pyridine and pyrazine derivative for the treatment of cystic fibrosis
30. Novel modulators of the nicotinic acetylcholine receptors
31. Heteroaryl-substituted piperidinyl urea compounds as FAAH inhibitors
32. Fatty acid amide hydrolase (FAAH) inhibitors for treating rheumatoid arthritis and pain
33. Serotonin (5-HT) and norepinephrine (NE) reuptake inhibitor compounds for treating pain disorder
34. Platelet activating factor (PAF) receptor antagonist for treating atherosclerosis
35. Biologically active amide ligands of NPY Y5 receptor treating cognitive disorders
36. Combination therapy for Parkinson’s disease
37. Combination therapy for epilepsy
38. Dihydroquinazoline inhibitors of BACE1 for treating Alzheimer’s disease
39. Treatment of pain with opioid analgesic dosage forms which are less subject to abuse
40. Prodrug compound of a rapamycin analog for treating restenosis
41. CCR1 antagonists for treating inflammatory diseases
42. Novel calcium receptor modulating agents for treating hyperparathyroidism
43. Oxadiazoles fused heterocyclic derivatives as selective S1P1 agonists for treating multiple sclerosis
44. Stable solid forms of modulators of CFTR for treating cystic fibrosis
45. Nitrate derivatives of cilostazol for the treatment of vascular and metabolic diseases
46. Pyrazole compounds as CCR1 antagonists for treating rheumatoid arthritis and multiple sclerosis
47. New imidazolidinedione derivatives for treating malaria
48. Modulators of store-operated calcium channels for the treatment of multiple sclerosis, rheumatoid arthritis and ulcerative colitis
49. dsRNA inhibiting the expression of a human E6AP gene for treating HPV infection
50. Combination therapy for pain
51. Novel N-heteroaryl-benzamides as glucokinase activators for treating type 2 diabetes
52. Inhibitors of AraC-XylS family and MarA family transcription factors as antibacterial drug targets
53. Dual-acting compounds for treating hypertension
54. Heterocyclic compounds as mGluR5 antagonists for treating anxiety, mood disorder, and depression
55. Novel caspase-6/-3 inhibitors for treating Huntington’s disease
56. Epothilone D for treating Alzheimer’s disease
57. Inhibitors of the mitotic kinesin KSP for the treatment of various diseases
58. Thiol derivative of ethyl mercury is thimerosal for treating viral infections
59. ANT4 as drug target for inducing contraception in a male
60. Carnitine palmitoyl transferase 1 (CPT1) enzyme inhibitors for the treatment of various diseases

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