Sciclips's Blog

Archive for October 2011


Highlights of recent US patents (issued) and US/WO(PCT) patent applications:

1. AIMP1 protein as a novel biomarker for the diagnosis of rheumatoid arthritis or osteoarthritis
2. Cerebrospinal fluid (CSF) biomarkers for the diagnosis of cancer, rheumatoid arthritis, asthma, diabetes, and obesity
3. Biomarkers for diagnosing auto-immune chronic urticaria
4. MicroRNA (miRNA) biomarkers for determining the risk level of a neuroblastoma patient
5. Biomarkers for predicting post-lung transplantation complications
6. Biomarkers for the prognosis of the progression of septic syndrome in a patient
7. Biomarkers for determining a patient’s susceptibility of contracting a nosocomial infection
8. Novel biomarkers for the diagnosis of diabetes
9. Biomarker associated with increased risk in developing a cardiovascular disease, or an autoimmune disease or inflammatory diseases
10. Autoantigen biomarkers for the diagnosis of type 1 diabetes
11. ATF2 and SH3GL2 as autoantigen biomarkers of systemic lupus erythematosus (SLE)
12. Biomarkers for predicting the clinical response to antidepressants
13. HLA complexes for predicting drug induced adverse reactions
14. Biomarkers for predicting the response of a patient with ankylosing spondylitis to anti-TNFalpha therapy
15. Gene expression markers for the diagnosis and prognosis of preeclampsia
16. Point-of-care (POC) devices for stress response profiling in saliva
17. CXCL3 as a biomarker of colon cancer
18. Serum biomarkers of differentiating chronic obstruction pulmonary disease (COPD) and lung cancer patients
19. Sirtuin assay

Details: http://www.sciclips.com/sciclips/biomarker-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?
3. Cell based reporter assays: misleading approach in drug discovery?

Related tools:

1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news
5. Comprehensive cancer biomarker database with companion diagnostics pathway

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Highlights of recent US patents (issued) and US/WO(PCT) patent applications:

1. Agouti-related protein as a biomarker for schizophrenia
2. MMP-3 as a biomarker for major depressive disorder
3. ABCG2 and CD44 as colon cancer stem cell markers
4. Serum amyloid A (SAA) as a biomarker for the diagnosis of myocardial infarction
5. Molecular method for the detection of Candida albicans
6. Eotaxin-3 as a biomarker for eosinophilic esophagitis
7. Biomarkers of oxidative stress
8. SNP markers for determining the prognosis of a clinical response to antidepressants
9. Cell based assay for the diagnosing interstitial cystitis
10. IL-17 as a biomarker for predicting the efficacy of IFN-beta therapy in multiple sclerosis patients
11. Hypoxia-inducible protein 2 (HIG2) as a diagnostic biomarker for clear cell renal cell carcinoma
12. mGluR4 imaging markers for the diagnosis of CNS disorders
13. Benzothiazoles as diagnostic imaging biomarkers of Alzheimer’s disease
14. EMT and tumor stem cell markers as surrogate markers to stratify breast cancer patients for personalized therapies
15. Soluble endoglin as a biomarker for diagnosing pre-eclampsia and eclampsia
16. Serum biomarker for the early on-set detection of a renal tubular cell injury
17. Diagnosing Alzheimer’s disease using a giant magnetoresistance sensor
18. Non-invasive prenatal diagnosis of Down’s syndrome and Turner’s syndrome using maternal plasma
19. Peripheral blood immune cell based method for diagnosing allergic asthma in patients
20. Biomarkers in the patient’s Bruch’s membrane for the diagnosis of age-related macular degeneration
21. A panel of multiple serum biomarkers for the diagnosis of major depressive disorder
22. Apolipoprotein CIII as a diagnostic biomarker of type I diabetes
23. Beta arrestin 2 as a biomarker for the diagnosis of insulin resistance
24. A cell based method for diagnosing asthma
25. Prenatal diagnosis of a fetal chromosomal aneuploidy
26. Personalized medicine approach for FOLFOX treatment in cancer patients
Details: http://www.sciclips.com/sciclips/biomarker-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?
3. Cell based reporter assays: misleading approach in drug discovery?

Related tools:

1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news
5. Comprehensive cancer biomarker database with companion diagnostics pathway


Highlights of recent US patent applications in drug discovery published on September 29, 2011:

1. Nicotinic acetylcholine receptor as a drug target for the treatment of peripheral nerve sensory loss
2. New kinase inhibitors for enhancing memory and learning and for treating Alzheimer’s disease
3. Combination therapy for treating psoriasis
4. Combination of glucocorticoid receptor (GR) ligand and a V-ATPase inhibitor for treating autoimmune and inflammatory diseases
5. Soluble CD47 binding for treating autoimmune and inflammatory disorders
6. DEPDC1- ZNF224 protein interaction as a therapeutic drug target for treating bladder cancer
7. Splice-splice switching oligomers for TNF superfamily receptors for the treatment of various diseases
8. Bicyclic peptidomimetic inhibitors of aspartyl-proteases for the treatment of infectious diseases
9. Triazolopyrimidinones as fatty acid binding protein (FABP) inhibitors
10. Spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers
11. Combination therapy for treating infantile spasms or refractory adult seizureshttps://sciclips.wordpress.com/?p=500&preview=true
12. Combination therapy for the treatment of fungal infections
13. Compounds having the capability to release carbon monoxide (CO) in vivo for treating rheumatoid arthritis
14. Compounds that inhibit MMP-9, VEGFR2 and inflammation-mediated cytokines for treating dry eye syndrome and inflammatory eye disease
15. Beta-N-acetylglucosaminidase as a drug target for treating lysosomal storage disorders
16. Vanoxerine for treating cardiac arrhythmia
17. Combination therapy for treating schizophrenia
18. Huperzine A derivatives for treating migraine
19. siRNA targeting ZEB1 and BLIMP-1 for treating asthma
20. siRNA targeting transthyretin for treating leptomeningeal amyloidosis or familial amyloid polyneuropathy
21. siRNA targeting ZFAT gene for the treatment of leukemia
22. Alpha-1-antitrypsin for the treatment of tissue necrosis
23. Artificial microRNA based acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1) inhibitors for treating Alzheimer’s disease
24. Chromenone derivatives as transient receptor potential vanilloid 3 (TRPV3) antagonists
25. Oral composition containing daidzein and cyanidin for treating acne
26. Treating muscle wasting in patients with non-small cell lung cancer (NSCLC)
27. Combination therapy for treating polycythemia vera
28. Vitamin U for healing wounds and improving skin wrinkles
29. Monocholine succinate salts for the treatment of depression, anxiety, schizophrenia, sleep disorder, and epilepsy
30. S1P receptor modulators for treating multiple sclerosis
31. Transglutaminase II inhibitors, as a tocolytic agent, for treating preterm labour
32. Nanoparticle based photodynamic therapy for the treatment of cancer
33. Systemic drug delivery through nails
34. Proliferation inhibitor of Helicobacter pylori
35. Contraceptive peptide from spider venom

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?
3. Cell based reporter assays: misleading approach in drug discovery?

Related tools:

1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news
5. Comprehensive cancer biomarker database with companion diagnostics pathway


Highlights of US patent applications published on September 29, 2011:

1. Biomarker for predicting increased risk of coronary heart disease (CHD) in patients with type 2 diabetes.
2. Diagnostic biomarker for brain disease caused by brain injury .
3. Gene expression biomarkers for the diagnosis and prognosis of prostate cancer patients.
4. Total FVII protein as a biomarker of pre-eclampsia.
5. Biomarkers of IgA nephropathy or TGBM nephropathy.
6. Serum biomarker panel for the diagnosis of Alzheimer’s disease.
7. PSA glycans as biomarkers for the diagnosis of prostate cancer.
8. Exosomal biomarkers for the diagnosis of prostate cancer and colon cancer.
9. Biomarkers for the diagnosis of exposure to electromagnetic radiation.
10. Phage microarrays for the diagnosis of prostate cancer.
11. LTBP2 as a biomarker of renal dysfunction.
12. LTBP2 as predictive marker for mortality in patients with acute dyspnea.
13. NMR based diagnosis of asthma, COPD and other respiratory diseases using metabolomic biomarkers.
14. Predicting chemotherapy outcome for individualized cancer treatment.
15. MicroRNA biomarkers for the diagnosis of motor neuron diseases.
16. Protein polymorphism biomarkers in human hair for paternity testing and forensic analysis.
Details: http://www.sciclips.com/sciclips/biomarker-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?
3. Cell based reporter assays: misleading approach in drug discovery?

Related tools:

1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news
5. Comprehensive cancer biomarker database with companion diagnostics pathway


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