Sciclips's Blog

Recent US Patent Applications in Drug Discovery

Posted on: October 5, 2011


Highlights of recent US patent applications in drug discovery published on September 29, 2011:

1. Nicotinic acetylcholine receptor as a drug target for the treatment of peripheral nerve sensory loss
2. New kinase inhibitors for enhancing memory and learning and for treating Alzheimer’s disease
3. Combination therapy for treating psoriasis
4. Combination of glucocorticoid receptor (GR) ligand and a V-ATPase inhibitor for treating autoimmune and inflammatory diseases
5. Soluble CD47 binding for treating autoimmune and inflammatory disorders
6. DEPDC1- ZNF224 protein interaction as a therapeutic drug target for treating bladder cancer
7. Splice-splice switching oligomers for TNF superfamily receptors for the treatment of various diseases
8. Bicyclic peptidomimetic inhibitors of aspartyl-proteases for the treatment of infectious diseases
9. Triazolopyrimidinones as fatty acid binding protein (FABP) inhibitors
10. Spiro azepane-ox-azolidinones as voltage gated Kv1.3 potassium channel blockers
11. Combination therapy for treating infantile spasms or refractory adult seizureshttps://sciclips.wordpress.com/?p=500&preview=true
12. Combination therapy for the treatment of fungal infections
13. Compounds having the capability to release carbon monoxide (CO) in vivo for treating rheumatoid arthritis
14. Compounds that inhibit MMP-9, VEGFR2 and inflammation-mediated cytokines for treating dry eye syndrome and inflammatory eye disease
15. Beta-N-acetylglucosaminidase as a drug target for treating lysosomal storage disorders
16. Vanoxerine for treating cardiac arrhythmia
17. Combination therapy for treating schizophrenia
18. Huperzine A derivatives for treating migraine
19. siRNA targeting ZEB1 and BLIMP-1 for treating asthma
20. siRNA targeting transthyretin for treating leptomeningeal amyloidosis or familial amyloid polyneuropathy
21. siRNA targeting ZFAT gene for the treatment of leukemia
22. Alpha-1-antitrypsin for the treatment of tissue necrosis
23. Artificial microRNA based acyl-CoA:Cholesterol Acyltransferase 1 (ACAT1) inhibitors for treating Alzheimer’s disease
24. Chromenone derivatives as transient receptor potential vanilloid 3 (TRPV3) antagonists
25. Oral composition containing daidzein and cyanidin for treating acne
26. Treating muscle wasting in patients with non-small cell lung cancer (NSCLC)
27. Combination therapy for treating polycythemia vera
28. Vitamin U for healing wounds and improving skin wrinkles
29. Monocholine succinate salts for the treatment of depression, anxiety, schizophrenia, sleep disorder, and epilepsy
30. S1P receptor modulators for treating multiple sclerosis
31. Transglutaminase II inhibitors, as a tocolytic agent, for treating preterm labour
32. Nanoparticle based photodynamic therapy for the treatment of cancer
33. Systemic drug delivery through nails
34. Proliferation inhibitor of Helicobacter pylori
35. Contraceptive peptide from spider venom

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?
3. Cell based reporter assays: misleading approach in drug discovery?

Related tools:

1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news
5. Comprehensive cancer biomarker database with companion diagnostics pathway

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