Sciclips's Blog

Archive for February 2012

Following are the new categories added to the Bioprotocols section. This bioprotocol database contains a unique list of protocols that are linked to open access journal articles, patents (issued) and patent applications. More than 10,000 protocols are listed in this database.

Next Generation Sequencing Protocols: A comprehensive list of next generation sequencing protocols for human, bacteria, virus, plants and other organisms.

Nanoparticles: Drug delivery, Imaging and Theranostics Protocols: The protocol categories include:Nanoparticle based Drug delivery & assays/immunoassays/imaging and preparation & characterization of nanoparticles.

Pharmaceutical Drug Formulation Protocols: The protocols categories include:General pharmaceutical drug formulation and nanoparticle based drug formulation protocols.

Raman Spectroscopy (Biomarker,Drug discovery and Theranostics Applications) Protocols: The protocols listed are related to the applications of Raman spectroscopy in biomarker discovery/imaging, cancer diagnosis, drug efficacy evaluation, drug composition analysis, protein/DNA/metabolite analysis, drug discovery assays and theransotics. The methods include coherent anti-Stokes Raman scattering (CARS),surface enhanced Raman spectroscopy (SERS),Tip-enhanced Raman scattering (TERS) etc.

Metabolomics Protocols: A comprehensive list of metabolomics protocols related to biomarker and drug discovery.

Next Generation Sequencing Bioinformatics Tools & Databases: A comprehensive list of open access bioinformatics tools and database for next generation sequencing data analysis.

Circulating Tumor Cells (CTCs) Protocols: A comprehensive list of open access circulating tumor cells (CTCs) protocols

Mitochondrial Drug Discovery Protocols: A comprehensive list of open access mitochondrial drug discovery protocols

Related tools:
1. Comprehensive cancer biomarker database with companion diagnostics pathway
2. Biomarker discovery protocols (descriptive protocols)
3. Drug discovery protocols(descriptive protocols)
4. Drug discovery news
5. Biomarker discovery news


Highlights of recent US patent applications on protein biomarkers and molecular diagnostics.

1. Biomarkers associated with early death in the general population
2. New predictive biomarker of response to cetuximab in metastatic colorectal cancer patients
3. Predictive biomarker of response to combination therapy in metastatic colorectal cancer patients
4. SNP markers for the determination the risk of developing schizophrenia
5. Serum biomarkers for the diagnosis and prognosis of dengue fever (DF)
6. Protein biomarkers for the diagnosis and predicting premature birth (PTB)
7. Endocan as a serum biomarker of sepsis
8. Gene expression markers for diagnosis and prognosis of lung cancer
9. A novel microRNA for the diagnosis of cardiovascular disorders
10. Biomarker panel for the diagnosis and monitoring the progression and treatment of stroke
11. Biomarker panel for the diagnosis of schizophrenia or other psychotic disorders
12. Multiplex bead array based assays for the diagnosis of autoimmune diseases
13. Biomarkers for predicting mortality and detecting the presence of severe disease
14. BRCA Ashkenazi mutation specific antibody test for breast cancer
16. BRCA tissue truncation test for the diagnosis of breast cancer
17. Urinary biomarkers for the diagnosis of preeclampsia
18. Biomarker panel for the diagnosis and prediction of graft rejection

Details: http://www.sciclips.com/sciclips/biomarker-news.do

Related tools:
1. Comprehensive cancer biomarker database with companion diagnostics pathway
2. Biomarker discovery protocols
3. Drug discovery protocols
4. Bioprotocols
5. Drug discovery news

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Following are the highlights of recent US patent applications related to cancer drug discovery. Details of each patent application with link to respective patents are available in the website.

1. Targeted drug delivery of liposome encapsulated drugs with cancer-targeting peptides for breast cancer therapy
2. miR-31 as a therapeutic drug target of breast cancer
3. Combination therapy for non-small cell lung cancer (NSCLC) using choline kinase inhibitors
4. Tumor marker protein SIMA135 for cancer diagnostic therapy (theranostics)
5. In vitro method for producing colorectal cancer cell derived microtumors
6. AMPK activator for the treatment of cancer having an aberrant EGFR or KRAS genotype
7. Screening phage-displayed antibodies that bind to radiation-inducible targets
8. BRCA1 based selection of treatment strategy for breast cancer, ovarian cancer and prostate cancer patients
9. mAR s a therapeutic target for enhancing the effectiveness of chemotherapy in glioblastoma patients
10. Peptide modified metal nanoparticle bioconjugates targeting GIPC/synectin for the treatment of cancer
11. New FGFR kinase inhibitors for the treatment of cancers expressing FGFR or PDGFR mutants
12. Fluorescent lymphatic mapping for sentinel lymph node (SLN) biopsy procedure
13. UV-controlled doxorubicin release from liposomes
14. RTD protein – a novel therapeutic modulator of apoptosis
15. PASD1 protein as a cancer vaccine target for B-cell tumours
16. TNF superfamily cytokines fused with collectin family trimerization domain for the treatment of cancer and other diseases

Link: http://www.sciclips.com/sciclips/drug-discovery-news.do

Related blogs:
1. Strategies for Rational and Personalized Cancer Biomarker Discovery

2. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Recent Patents on Theranostics

Related tools:

5. Comprehensive cancer biomarker database with companion diagnostics pathway
1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news

Following are the highlights of drug discovery related recent US patent applications. Details of each patent application with link to respective patents are available in the website.

1. Flurbiprofen for the treatment of leptin resistance
2. Tyrosinase inhibitors for the treatment and prevention of pigmentary disorders
3. Selective induction of terminal differentiation, cell growth arrest or apoptosis of cancer cells
4. Method for treating altitudinal hypoxia – hypoxia resulting from reduced oxygen levels at high altitude
5. Antisense oligonucleotides targeting exon skipping in the dystrophin gene for the treatment of Duchenne Muscular Dystrophy
6. Antisense oligonucleotide targeting IRS-1 for the treatment of ophthalmic pathological neovascularization-related diseases
7. PPAR gamma agonists, sulfonamide compounds, for the treatment of chronic obstructive pulmonary disorder (COPD) and asthma
8. A novel pyridine thio derivative for the treatment of Helicobacter pylori infection
9. T cell alpha-2B adrenergic receptors as therapeutic drug target for the treatment of various human diseases
10. siRNA targeting MIG12 gene for the treatment of lipid disorders
11. Prodrugs of GABA analogs
12. Endogenous hyaluronan synthesis as a drug target for the cosmetic treatment of aged skin
13. A medical food for the treatment of autism, ADHD and childhood psychotic disorder
14. TNF superfamily cytokines fused with collectin family trimerization domain for the treatment of cancer and other diseases
15. PTGS suppressor PTGS suppressor protein binding inhibitor as an antiviral agent
16. Extended release of drugs with pH dependent solubility [Patent News]
17. Combination of sodium-dependent glucose transporter (SGLT2) inhibitor and biguanide for the treatment of diabetes
18. Tapentadol for the treatment of osteoarthritis pain
19. Genetic variants at SMAD3 and/or JAK2 loci as diagnostic and prognostic biomarkers of inflammatory bowel disease (IBD)
20. Frataxin as a therapeutic drug target of Friedreich’s ataxia
Link: http://www.sciclips.com/sciclips/drug-discovery-news.do

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Recent Patents on Theranostics

Related tools:

5. Comprehensive cancer biomarker database with companion diagnostics pathway
1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news

Note: Following are the highlights of recent patent applications on next generation sequencing. Complete review of next generation sequencing related patent searches and data mining are available through Sciclips consultancy services.

1. Terminal tagging oligoribonucleotide (rTTO) to join a DNA sequence tag to the 3′-termini of first-strand cDNA molecules
2. A ligation-based method and a kit for preparing a template for next generation sequencing
3. Next generation sequencing method for noninvasive prenatal diagnostics
4. High-throughput next generation sequencing DNA markers for treating, diagnosing, and prognosing lung cancer
5. Next generation sequencing method of predicting the risk of a patient for developing COX-2 inhibitor lumiracoxib induced hepatotoxicity
6. Next generation sequencing method for determining the primary site of a cancer of unknown primary site (CUP)
7. Next generation sequencing method for diagnosing Noonan-like syndrome with loose anagen hair
8. Next generation sequencing method for the diagnosis of Alzheimer’s disease
9. Method for high throughput paired-end sequencing of large-insert clone libraries for next generation sequencing
10. Next generation sequencing method for determining the increased risk for developing degenerative neurological or psychiatric diseases
11. Identification of fetal nucleic acid fraction in a mixture of fetal and maternal nucleic acids using next generation sequencing
12. Next generation sequencing method for predicting the risk of developing late onset Alzheimer’s disease
13. Whole genome sequencing methods for identifying polymorphisms in blood sample
14. Next generation sequencing methods for diagnosing presence or increased risk of developing an autism spectrum disorder
15. Next generation sequencing method for determining the genome of an unborn fetus of a pregnant female

Details: http://www.sciclips.com/sciclips/biomarker-news.do

Related blogs:

1. Sciclips Consultancy Services
2. Companion diagnostics or Theranostics Products in the Market
3. Recent Patents on Theransotics
4. Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Related tools:

1. Next generation sequencing bioinformatics tools and analysis
2. Comprehensive cancer biomarker database with companion diagnostics pathway
3. Drug discovery protocols
2. Bioprotocols
4. Drug discovery reagents
5. Drug discovery news

Following are some of the companion diagnostics or theranostics products that are currently available (may not be available worldwide), in addition to the US FDA approved Genetech’s Hercept® with DakoCytomation’s HercepTest® for breast cancer and Roche’s Zelboraf ® and companion diagnostic test for late-stage skin cancer.

1. DNA tests for Heart medication | Clopidogrel Genetic Test (from Theranostics Lab).
2. DNA tests for Heart medication | Statin Genetic Test (from Theranostics Lab).
3. DNA tests for Heart medication | Warfarin Genetic Test (from Theranostics Lab).
4. AtheroAbzyme™ ELISA (from Cambridge Theranostics) – this test is used for identifying the risk of developing diseases caused by the oxidation of lipids due to the presence of active ALOA (Atherogenic Lipid-Oxidising Antibodies). This test can also be used for monitoring patients who were treated with anti – ALOA.
5. CancerTYPE ID® (from bioTheranostics) – a molecular diagnostic test for the determination of tumor site of origin using differential expression of 92 genes.
6. Breast Cancer IndexSM- (from bioTheranostics) – a prognostic biomarker based test for the quantitative assessment of the likelihood of distant recurrence in estrogen receptor-positive, lymph node-negative breast cancer patients.
7. PRÉCISSM Precision Medicine (from bioTheranostics) – biomarker profiling based test for the detection of clinically relevant tumor biomarkers for non-small cell lung cancer (NSCLC) and colorectal cancer.
8. Therapy Selection Assay for Ductal Carcinoma in Situ (Breast Cancer) (from Target Discovery).
9. Tumor Aggressiveness Assay for Prostate Cancer (from Target Discovery).
10. Chemotherapy Selection in Ovarian Cancer (from TargetDiscovery).
11. CVDefine® kit: ELISA based immunoassay kit for the early detection of lesions in the artery wall caused by inflammation (from Athera Biotechnologies AB).
12. Aetiological diagnosis of AKI (from Bio-inRen)- urinary marker based test for monitoring hypertension and antihypertensive therapy efficacy.
13. Acquired risk of kidney injury (from Bio-inRen)- biomarkers based test to detect patients with increased risk of developing acute kidney injury from a drug treatment.
14. InformMDx (from MDxHealth)– prognostic assay for differentiating aggressive and non-aggressive tumors (prostate and lung cancer) (product pipeline).
15. PredictMDx (from MDxHealth)–a predictive test to identify which drug or treatment regimen is likely to be most effective for prostate and lung cancer patients (product pipeline).

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Recent Patents on Theranostics

Related tools:

5. Comprehensive cancer biomarker database with companion diagnostics pathway
1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news


Note: Following are the highlights of recent theranostics (diagnostic therapy) patent applications. Complete review of theranostics related patent searches and data mining are available through Sciclips consultancy services.

1. Theranostic classification of basal-like breast cancer tumors
2. Diagnostic therapy method (theranostics) for Aspergillus fumigates infections
3. Theranostics method for premature birth (PTB)
5. Theranostic chitosan-coated gold/gold sulfide nanoparticles
6. Theranostic compounds for the management of diseases manifesting focal hypoxia
7. PBEF1 gene expression as a theransotic biomarker for HIV-related diseases
8. Theranostic methods for the treatment of cancers using mannose derivatives
9. Prepraration of photosensitive ruthenium based aminoacid monomers and oligomers for imaging and theranostics applications
10. A diagnostic therapy (theranostics) method for multiple myeloma patients
11. System for generating image-based patient profiles
12. Method of predicting or identifying response to treatment with a modulator of a reverse cholesterol transport pathway in atherosclerosis patients
13. Biomarkers for the detection of the presence and for the theranostics of unstable atherosclerotic plaques
14. Spectral imaging for medical diagnosis
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

Related blogs:

1. Sciclips Consultancy Services
2. Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Related tools:

5. Comprehensive cancer biomarker database with companion diagnostics pathway
1. Drug discovery protocols
2. Bioprotocols
3. Drug discovery reagents
4. Drug discovery news


Comprehensive Cancer Bomarker Database

Sciclips consultancy

Diagnostic & Prognostic Biomarker Database

Bioprotocol database (open access)

Combination therapy database (open access)

Therapeutic drug target database (open access)

Bioinformatics databases (open access)

Stem cell researchers database

A comprehensive database for stem cell researchers, Stem cell research reagents, Stem cell patents, Stem cell grants, Stem cell clinical trials, Stem cell statistics, Stem cell news and Stem cell open innovation ideas. Please visit http://www.sciclips.com/

Sciclips consultancy

Proteomics researchers database

A comprehensive database for proteomics researchers, Proteomics research reagents, Proteomics patents, Proteomics grants, Proteomics clinical trials, Proteomics statistics, Proteomics news and Proteomics open innovation ideas. Please visit http://www.sciclips.com/

Share or sell research reagents prepared in your laboratory

Drug target database (open access)

Pharmacogenomics protocols online

Proteomics and Mass spectrometry (MS) protocols online

Therapeutic drug targets database (open access)

Drug discovery, Biopharmaceuticals, HTS assays protocols online

Protein display/Protein engineering/Directed evolution protocols online

Molecular biology and Cell biology protocols online

siRNA protocols miRNA protocols online

Video protocols

Cell culture video protocols, Cytotoxicity assay video protocols, Stem cell video protocols, Molecular biology video protocols http://www.sciclips.com/sciclips/video-protocols.do

Sciclips consultancy

Sciclips

Bioprotocols online (open access)

Combination therapy database (open access)

Therapeutic drug targets database (open access)

Bioinformatics databases (open access)

HTS assay protocols online (open access)