Recent Drug Discovery Patent Applications

Posted by: sciclips on: March 20, 2012

• In: Drug discovery | Drug targets
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Following are the highlights of recent US patent applications on drug discovery. Details of each patent application with link to respective patents are available in the website.

Cancer

1. Protein kinase CK2 inhibitors for the treatment of cancer
2. Macrophage-stimulating protein receptor (MSP-R or RON) as a drug target for the treatment of cancer
3. Anti-K63-linked polyubiquitin monoclonal antibodies for the treatment of cancer, muscular, immune/inflammatory and neurological disorders
4. Oligonucleotide based drugs for the treatment of B-cell leukemias
5. Next-generation photosensitive medical agent that can simultaneously diagnose cancer and carry out photodynamic therapy (PDT)
6. Combination therapy for melanoma
7. MicroRNAs as therapeutic drugs for the treatment of sarcoma
8. Dual targeting antibodies of VEGFR-2 and Tie-2 receptors for treating cancer
9. A novel chlorin e6-folic acid conjugate for photodynamic therapy of malignant and solid tumors
10. Autotaxin inhibitors for the treatment of cancer
11. MicroRNA (miRNA) as therapeutic drugs for treating cancer
12. Anti-VCAM1-tTF coaguligand for treating cancer
13. Anti-phoshatidylserine antibody-docetaxel combination therapy for the treatment of cancer
14. Targeted cancer therapy using miR-21 promoter driven expression of anti-cancer agents
15. miRNA-184 as therapeutic drug for treating squamous cell carcinoma

Anti-aging

1. Extending lifespan in humans by altering the expression of stress activating proteins
2. Improving wrinkles or preventing aging using panduratin derivatives or Kaempferia pandurata extract

Neurodegenerative and Neuropsychiatric diseases

1. Advanced glycation end products (AGE) as a therapeutic drug target for treating schizophrenia
2. Compounds that relieve axonal blockages for the treatment of neuropathies and neurodegenerative diseases
3. PDE10A enzyme inhibitors for treating neurodegenerative and psychiatric disorders

Viral, Metabolic and Autoimmune diseases

1. MCP-1 derived oligopeptides for the treatment of HIV infection
2. Monoclonal antibodies for treating Hendra virus and Nipah virus infections
3. A novel dengue vaccine
4. Stearoyl-CoA desaturase inhibitors for treating cardiovascular disease, cancer, diabetes, obesity and metabolic syndromes
5. Alpha 4 beta 1 integrin selective inhibitors for the treatment of multiple sclerosis
6. Combination therapy for treating type 2 diabetes
7. siRNAs targeting MAP4K4 for treating metabolic disorders
8. Preadipocytes as drug target for treating obesity
9. IdeS protein for treating arthritis
10. Orexin antagonists for treating obesity

Cardiovascular diseases

1. Biological pacemaker (bio-pacemaker)
2. Inhibitors of platelet aggregation for reducing the risk of thrombocytopenia-associated mortality and morbidity
3. NOTCH pathway inhibitors for the treatment of atherosclerosis
4. S1P1/EDGE1 receptor agonists for treating uncontrolled inflammatory disease and to improve vascular functionality
5. T-type calcium channel inhibitors for treating cardiovascular diseases, epilepsy and pain
6. Vanilloid receptor 1 (VR1) antagonists for treating pain

Eye and Respiratory diseases

1. STAT3 inhibitors for treating age related macular degeneration (AMD)
2. Valproic acid microspheres for the treatment of age-related macular degeneration (AMD)
3. ROCK kinase inhibitors for treating glaucoma
4. Antisense oligonucleotides for treating asthma
5. Biphenyl compounds as muscarinic receptor antagonists for treating chronic obstructive pulmonary disease (COPD) and asthma
6. Brain-derived neurotrophic factor (BDNF) as a therapeutic drug target for treating amblyopia
7. Gremlin as a drug target for treating glaucoma

Miscellaneous diseases

1. Alpha-2-delata ligands for treating non-restorative sleep
2. A cell based reporter assay for the detection of uric acid (uric acid sensor)
3. Dopamine reuptake inhibitors for treating hot flush in pre-menopausal women
4. Compounds that enhance both the transcription activity of Runx2 and the expression level of alkaline phosphatase for treating osteroporosis
5. Melatonin receptors as a therapeutic drug target for treating insomnia
6. Method for treating early morning akinesia
7. mGlu5 antagonists for treating neuromuscular dysfunction of the lower urinary tract and gastroesophageal reflux disease (GERD)
8. Anti-SLAM family member 7 (CS1) antibodies for the treatment of SLE, IBD and myeloma
9. A novel class of C5a complement inhibitors
10. Orexin receptor antagonists for treating eating disorders and drinking disorders
11. Phosphodiesterase (PDE 5) as a therapeutic drug target for treating Peyronie’s disease (PD)
12. Bi-specific antibodies for the treatment of allergy
13. Soluble IL-22R/IL-20RB heterodimeric protein for the treatment of psoriasis
14. Phosphorous transport inhibitors for the treatment of hyperphosphatemia

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

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Tags: Advanced glycation end products, age-related macular degeneration drug target, Alpha 4 beta 1 integrin selective inhibitors, amblyopia drug target, AMD drug target, Anti-CS1 antibodies, Anti-SLAM family member 7 antibodies, asthma oligonucleotide drug, Autotaxin inhibitors, bio-pacemaker, Biological pacemaker, C5a complement inhibitors, dengue vaccine, diagnostic imaging, Dopamine reuptake inhibitors, early morning akinesia drug target, gastroesophageal reflux disease drug target, GERD drug target, glaucoma drug target, Hendra virus monoclonal antibodies, hot flush drug target, hyperphosphatemia, insomnia drug target, Kaempferia pandurata extract, MCP-1 peptides, Melatonin receptors, mGlu5 antagonists, multiple sclerosis drug target, Nipah virus monoclonal antibodies, non-restorative sleep drug target, NOTCH pathway inhibitors, Orexin antagonists, Orexin receptor antagonists, panduratin derivatives, Peyronie's disease drug target, Phosphorous transport inhibitors, platelet aggregation inhibitors, relieve axonal blockages, ROCK kinase inhibitors, S1P1/EDGE1 receptor agonists, schizophrenia drug target, STAT3 inhibitors, Stearoyl-CoA desaturase inhibitors, T-type calcium channel inhibitors, Thrombocytopenia drug target, type 2 diabetes combination therapy, uric acid detection cell based assay, uric acid sensor, Valproic acid microspheres AMD, Vanilloid receptor 1 antagonists, VR1 antgonists