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Archive for October 2012


Highlights of recent US patents (issued and applications) on protein biomarkers and molecular diagnostics.

(Click on titles to view the details)

1. Gene expression biomarker panel for the prognosis of urinary bladder cancer.
2. Detection of cancer using multiplex Liquid Tissue Arrays TM derived from formalin-fixed tissues.
3. Detection of cancers using transcription infidelity domains.
4. Prognostic biomarkers of pancreatic cancer.
5. Circulating miRNA biomarkers of prostate cancer.
6. Protein biomarker for the detection of endometrial cancer.
7. Diagnosing hematological cancers using circulating tyrosine kinases (cTK).
8. Serum CD200 for detecting chronic lymphocytic leukemia (CLL).
9. Dection of granulocytic anaplasmosis caused by the tick-borne pathogen Anaplasma phagocytophilum.
10. VEGF-D for the diagnosis of lymphangioleiomyomatosis (LAM).
11. Diagnosis of babesiosis caused by tick-borne parasite Babesia microti.
12. Prognostic biomarkers of chronic heart failure (CHF).
13. Methods of diagnosing IgA nephropathy.
14. Mass spectrometry with high reproducibility using MALDI-TOF MS plate with nanodot regions.
15. Polymorphic markers of determining susceptibility to Atrial fibrillation, Atrial flutter, and Stroke.
16. Gene expression biomarkers for the detection of thrombocytosis.
17. Micro RNAs for diagnosing chronic obstructive pulmonary disease (COPD).
18. Free pregnancy associated plasma protein A (PAPP-A) for the diagnosis of acute coronary syndrome.
19. Soluble fms-like tyrosine kinase-1 (sFLT-1) for the diagnosis of myocardial infarction.
20. Genetic test for screening risk in developing Charcot-Marie-Tooth Disease Type 2A.
21. Molecular diagnostic assays for the diagnosis of bacterial vaginosis.

Related blogs on biomarkers:

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

How to Identify Clinically Successful Biomarkers?

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Metabolon vs. Stemina – Are Biomarkers Patents can be Considered as “True Inventions”?

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Comprehensive cancer biomarker database with companion diagnostics pathway

Bioprotocols database

This blog critically analyzes the limitations and pitfalls in biomarker patent process. According to the argument made in this blog, most of the biomarkers patents may not have commercial prospective, though patents are intend to protect the right to manufacture and sell invented products, due to the fact that these biomarkers were identified and characterized without following solid scientific principles and demonstrating clinical applications, which are indispensable for developing commercially viable products. Claimed inventions proposed in patents without adequate scientific research driven supporting evidences and reasonable interpretation of experimental results, as oppose to peer reviewed scientific publications, may not have any scientific value or may not be scientifically acceptable. These patents can also be scientifically mistaken and these patents may not only preclude innovation in biomarker discovery but also hinder the development of low-cost patient care diagnostics products. Read more: >> Metabolon vs. Stemina – Are Biomarkers Patents can be Considered as “True Inventions”?

Related blogs on biomarkers:

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

How to Identify Clinically Successful Biomarkers?

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Related tools:

Comprehensive cancer biomarker database with companion diagnostics pathway

Bioprotocols database

Launched an open access database of neuropsychiatric disease biomarker and drug discovery assays and protocols. The listed protocols are extracted from and linked to patents and journal articles. The innovative representation of protocols in this database will be a useful tool for idea/concept generation for developing innovative approaches for neuropsychiatric disease biomarker and drug discovery research. Please follow this link to see the complete list of protocols: Neuropsychiatric disease biomarker and drug discovery assays and protocols

Related blogs:

How to Identify Clinically Successful Biomarkers?

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Related tools:

Comprehensive cancer biomarker database with companion diagnostics pathway>

Bioprotocols database


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