Sciclips's Blog

Archive for the ‘Drug targets’ Category

Sciclips has launched a disease database along with discussion and networking forums. More than 13,000 human diseases were listed in this database. Researchers can post their research findings, patents news, clinical trial news etc. in these discussion forums designed for each diseases. The networking forum enables researchers, physicians etc. working on specific diseases to share their scientific interests and interact with each other. Please follow this link to visit the disease database: http://www.sciclips.com/sciclips/diseases-discussion-networking.do

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Bioprotocols database

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An open access database of rheumatoid arthritis (RA) biomarker and drug discovery assays and protocols. The listed protocols are extracted from and linked to patents and journal articles. The innovative representation of protocols in this database will be a useful tool for idea/concept generation for developing innovative approaches for RA biomarker and drug discovery research. Please follow this link to see the complete list of protocols: P : http://www.sciclips.com/sciclips/bio-protocols.do?catName=Rheumatoid%20arthritis%20%28RA%29%20biomarker%20and%20drug%20discovery%20assay

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1. Bioprotocols
2. Comprehensive cancer biomarker database with companion diagnostics pathway
4. Biomarker news

An open access database of biomarker and drug discovery assays/protocols  for neurodegenerative diseases. The listed protocols are extracted from and linked to patents and journal articles.  The innovative representation of protocols in this database will be a useful  tool for idea/concept generation for developing innovative approaches for Alzheimer’s disease and Parkinson’s disease biomarker and drug discovery research. Please follow this link to see the complete list of protocols: http://www.sciclips.com/sciclips/bio-protocols.do?catName=Neurodegenerative%20disease%20biomarker%20and%20drug%20discovery

Related tools:

1. Bioprotocols
2. Comprehensive cancer biomarker database with companion diagnostics pathway
4. Biomarker news

Following are the highlights of recent US patent applications on drug discovery. Details of each patent application with link to respective patents are available in the website.

1. Irreversible inhibitors of Bruton’s tyrosine kinase (Btk) for treating rheumatoid arthritis and asthma
2. Apple polyphenols as inhibitors of lectin-like oxidized LDL receptor for treating arteriosclerosis
3. Treating Alzheimer’s disease using hydroxychavicol isolated from Piper Betel
4. Panduratin derivative extracted from Boesenbergia pandurata for treating metabolic diseases
5. Jasmonic acid compound for treating greasy skin
7. Citrulline for treating aneurysmal subarachnoid hemorrhage
8. Modified amino acids as inhibitors of blood platelet aggregation
10. Halogenated prostaglandin analogs for treating constipation
12. Doxepin for treating insomnia in elderly patients
13. Taxol for treating atherosclerosis and restenosis
14. MicroRNA’s as therapeutic drug targets of head and neck cancer
15. IL-4R alpha antisense oligonucleotide therapy for asthma and allergic rhinitis
16. MicroRNAs as therapeutic drug targets for treating viral infections
17. Gadd45 as a therapeutic target of mood disorders
18. MicroRNAs as therapeutic drug targets of acute myeloid leukemia
19. T type calcium channel inhibitors for the treatment of cancer
20. Human type 2 taste receptor 8 (hT2R8) antagonists as bitter taste blockers
21. One day treatment with famciclovir for recurrent herpes labialis
22. BEC1 potassium channel inhibitor for treating attention deficit/hyperactivity disorder
23. Combination therapy for treating Charcot-Marie-Tooth disease
24. Tetracycline for treating meibomian gland disease
25. Voltage-dependent anion channel 1 (VDAC1) protein as a therapeutic drug target of Parkinson’s disease

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

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2. Cell based reporter assays: misleading approach in drug discovery?
3. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
4. Are stem cells ready as a next generation drug discovery tool?

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Therapeutic Drug Target Database: Contains more than 6000 therapeutic drug targets extracted from patents and patent applications.


Novel/Potential Drug Target Database:
Contains more than 3000 therapeutic drug targets extracted from journal articles.


Combination Therapy Database: Contains combination therapy methods for more than 1300 diseases (extracted from journal articles, patents and clinical trials).


Therapeutic and Experimental Drug Database: Contains more that 14,000 drugs extracted from patents and patent applications.


Cancer Biomarker Database: A comprehensive oncology biomarker database with companion diagnostics pathway analysis.


Bioprotocols Database: A unique list of bioprotocols linked to published journal articles and patents.



Drug Discovery News: Latest drug discovery news from patents and patent applications.



Sciclips Blog: Blogs on drug discovery, stem cells, proteomics, biomarkers and open innovation.




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2. Cell based reporter assays: misleading approach in drug discovery?
3. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?

Following are the highlights of recent US patent applications on drug discovery. Details of each patent application with link to respective patents are available in the website.

Cancer

1. Protein kinase CK2 inhibitors for the treatment of cancer
2. Macrophage-stimulating protein receptor (MSP-R or RON) as a drug target for the treatment of cancer
3. Anti-K63-linked polyubiquitin monoclonal antibodies for the treatment of cancer, muscular, immune/inflammatory and neurological disorders
4. Oligonucleotide based drugs for the treatment of B-cell leukemias
5. Next-generation photosensitive medical agent that can simultaneously diagnose cancer and carry out photodynamic therapy (PDT)
6. Combination therapy for melanoma
7. MicroRNAs as therapeutic drugs for the treatment of sarcoma
8. Dual targeting antibodies of VEGFR-2 and Tie-2 receptors for treating cancer
9. A novel chlorin e6-folic acid conjugate for photodynamic therapy of malignant and solid tumors
10. Autotaxin inhibitors for the treatment of cancer
11. MicroRNA (miRNA) as therapeutic drugs for treating cancer
12. Anti-VCAM1-tTF coaguligand for treating cancer
13. Anti-phoshatidylserine antibody-docetaxel combination therapy for the treatment of cancer
14. Targeted cancer therapy using miR-21 promoter driven expression of anti-cancer agents
15. miRNA-184 as therapeutic drug for treating squamous cell carcinoma

Anti-aging

1. Extending lifespan in humans by altering the expression of stress activating proteins
2. Improving wrinkles or preventing aging using panduratin derivatives or Kaempferia pandurata extract

Neurodegenerative and Neuropsychiatric diseases

1. Advanced glycation end products (AGE) as a therapeutic drug target for treating schizophrenia
2. Compounds that relieve axonal blockages for the treatment of neuropathies and neurodegenerative diseases
3. PDE10A enzyme inhibitors for treating neurodegenerative and psychiatric disorders

Viral, Metabolic and Autoimmune diseases

1. MCP-1 derived oligopeptides for the treatment of HIV infection
2. Monoclonal antibodies for treating Hendra virus and Nipah virus infections
3. A novel dengue vaccine
4. Stearoyl-CoA desaturase inhibitors for treating cardiovascular disease, cancer, diabetes, obesity and metabolic syndromes
5. Alpha 4 beta 1 integrin selective inhibitors for the treatment of multiple sclerosis
6. Combination therapy for treating type 2 diabetes
7. siRNAs targeting MAP4K4 for treating metabolic disorders
8. Preadipocytes as drug target for treating obesity
9. IdeS protein for treating arthritis
10. Orexin antagonists for treating obesity

Cardiovascular diseases

1. Biological pacemaker (bio-pacemaker)
2. Inhibitors of platelet aggregation for reducing the risk of thrombocytopenia-associated mortality and morbidity
3. NOTCH pathway inhibitors for the treatment of atherosclerosis
4. S1P1/EDGE1 receptor agonists for treating uncontrolled inflammatory disease and to improve vascular functionality
5. T-type calcium channel inhibitors for treating cardiovascular diseases, epilepsy and pain
6. Vanilloid receptor 1 (VR1) antagonists for treating pain

Eye and Respiratory diseases

1. STAT3 inhibitors for treating age related macular degeneration (AMD)
2. Valproic acid microspheres for the treatment of age-related macular degeneration (AMD)
3. ROCK kinase inhibitors for treating glaucoma
4. Antisense oligonucleotides for treating asthma
5. Biphenyl compounds as muscarinic receptor antagonists for treating chronic obstructive pulmonary disease (COPD) and asthma
6. Brain-derived neurotrophic factor (BDNF) as a therapeutic drug target for treating amblyopia
7. Gremlin as a drug target for treating glaucoma

Miscellaneous diseases

1. Alpha-2-delata ligands for treating non-restorative sleep
2. A cell based reporter assay for the detection of uric acid (uric acid sensor)
3. Dopamine reuptake inhibitors for treating hot flush in pre-menopausal women
4. Compounds that enhance both the transcription activity of Runx2 and the expression level of alkaline phosphatase for treating osteroporosis
5. Melatonin receptors as a therapeutic drug target for treating insomnia
6. Method for treating early morning akinesia
7. mGlu5 antagonists for treating neuromuscular dysfunction of the lower urinary tract and gastroesophageal reflux disease (GERD)
8. Anti-SLAM family member 7 (CS1) antibodies for the treatment of SLE, IBD and myeloma
9. A novel class of C5a complement inhibitors
10. Orexin receptor antagonists for treating eating disorders and drinking disorders
11. Phosphodiesterase (PDE 5) as a therapeutic drug target for treating Peyronie’s disease (PD)
12. Bi-specific antibodies for the treatment of allergy
13. Soluble IL-22R/IL-20RB heterodimeric protein for the treatment of psoriasis
14. Phosphorous transport inhibitors for the treatment of hyperphosphatemia

Details: http://www.sciclips.com/sciclips/drug-discovery-news.do

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1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Related tools:

1. Comprehensive cancer biomarker database with companion diagnostics pathway
2. Bioprotocols
4. Biomarker news

We have launched an open access therapeutic and experimental drugs database as a part of Sciclips’ initiatives for open innovation. This database contains a list of drugs that are primarily extracted from issued patents and patent applications. Each drug types are listed based on their functionality and associated drug targets. More than 15,000 drugs are currently listed in this database. The details of this database is available at http://www.sciclips.com/sciclips/therapeutic-experimental-drugs-main.do

This open access therapeutic and experimental drugs database will be helpful to the researchers who are in need of this information. Because of the complexity of the data presentation in patents or patent applications, often these valuable information do not reach the researchers in a timely manner. We believe this database will opens up new avenues for exploring innovative methods and tools for discovering new targets/drugs and may also help to avoid redundancy in drug discovery research. This database may also provide intelligent information on several key aspects such as drug targets and drug types, which are critical in drug discovery research.

In the past, Sciclps has launched several open access databases such as Therapeutic drug targets database, Novel and potential drug target database, Combination therapy database and Drug discovery news, primarily focused on reporting inventions from patents. This new therapeutic and experimental drugs database will be a valuable addition to our existing drug discovery open innovation platform. We will be expanding this database in coming months to include more small molecule drugs, biopharmaceutical drugs and additional information.

Related blogs:

1. Cell Based Reporter Assays vs. Animal Studies in Drug Discovery- Potential Limitations, Risks and Liabilities
2. Cell based reporter assays: misleading approach in drug discovery?
3. Cancer Theranostics – Potential Applications of Cancer Biomarker Database
2. Are stem cells ready as a next generation drug discovery tool?

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2. Biomarker discovery protocols (descriptive protocols)
3. Drug discovery protocols(descriptive protocols)
4. Drug discovery news
5. Biomarker discovery news


Comprehensive Cancer Bomarker Database

Sciclips consultancy

Diagnostic & Prognostic Biomarker Database

Bioprotocol database (open access)

Combination therapy database (open access)

Therapeutic drug target database (open access)

Bioinformatics databases (open access)

Stem cell researchers database

A comprehensive database for stem cell researchers, Stem cell research reagents, Stem cell patents, Stem cell grants, Stem cell clinical trials, Stem cell statistics, Stem cell news and Stem cell open innovation ideas. Please visit http://www.sciclips.com/

Sciclips consultancy

Proteomics researchers database

A comprehensive database for proteomics researchers, Proteomics research reagents, Proteomics patents, Proteomics grants, Proteomics clinical trials, Proteomics statistics, Proteomics news and Proteomics open innovation ideas. Please visit http://www.sciclips.com/

Share or sell research reagents prepared in your laboratory

Drug target database (open access)

Pharmacogenomics protocols online

Proteomics and Mass spectrometry (MS) protocols online

Therapeutic drug targets database (open access)

Drug discovery, Biopharmaceuticals, HTS assays protocols online

Protein display/Protein engineering/Directed evolution protocols online

Molecular biology and Cell biology protocols online

siRNA protocols miRNA protocols online

Video protocols

Cell culture video protocols, Cytotoxicity assay video protocols, Stem cell video protocols, Molecular biology video protocols http://www.sciclips.com/sciclips/video-protocols.do

Sciclips consultancy

Sciclips

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Bioprotocols online (open access)

Combination therapy database (open access)

Therapeutic drug targets database (open access)

Bioinformatics databases (open access)

HTS assay protocols online (open access)