Sciclips's Blog

Archive for the ‘Proteomics’ Category

Sciclips has launched a disease database along with discussion and networking forums. More than 13,000 human diseases were listed in this database. Researchers can post their research findings, patents news, clinical trial news etc. in these discussion forums designed for each diseases. The networking forum enables researchers, physicians etc. working on specific diseases to share their scientific interests and interact with each other. Please follow this link to visit the disease database: http://www.sciclips.com/sciclips/diseases-discussion-networking.do

Related blogs:

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Biomarker Strategy to Develop Companion Diagnostics for Predicting Prescription Drug Induced Tumors – Analysis using pioglitazone (Actos) and bladder cancer

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

How to Identify Clinically Successful Biomarkers?

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Metabolon vs. Stemina – Are Biomarkers Patents can be Considered as “True Inventions”?

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Comprehensive cancer biomarker database with companion diagnostics pathway

Bioprotocols database

Launched an open access database of neuropsychiatric disease biomarker and drug discovery assays and protocols. The listed protocols are extracted from and linked to patents and journal articles. The innovative representation of protocols in this database will be a useful tool for idea/concept generation for developing innovative approaches for neuropsychiatric disease biomarker and drug discovery research. Please follow this link to see the complete list of protocols: Neuropsychiatric disease biomarker and drug discovery assays and protocols

Related blogs:

How to Identify Clinically Successful Biomarkers?

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Related tools:

Comprehensive cancer biomarker database with companion diagnostics pathway>

Bioprotocols database

The decisive goal of clinical biomarker discovery should be intended for developing high quality and low-cost disease detection/monitoring assays with high diagnostic accuracy. Innovative approaches are warranted for the discovery of clinical biomarkers, with faster bench to clinics timeline, to provide high quality and efficient patient care. At the same time, if we continue with the strategic and technological approaches that are currently being adopted for biomarker discovery and validation, most likely, it may take several years to find clinically viable biomarker/s for complex diseases like cancer or neurodegenerative or autoimmune or other human diseases. Therefore, an ideal clinical biomarker discovery platform, which can lead to the development of reliable and robust clinical diagnostics assays, should adopt an integrated approach that consists of comprehensive understanding of patients’ phenotypic, genetic and socio-environmental characteristics as well as biological and functional relevance of all biomolecules. In order to achieve these goals, two models for the discovery, selection and validation of clinically viable biomarkers are proposed in this scientific blog. Read the full blog: How to Identify Clinically Successful Biomarkers?

Related blogs:

Strategies for Rational and Personalized Cancer Biomarker Discovery

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Related tools:

Comprehensive cancer biomarker database with companion diagnostics pathway


Highlights of recent US patents (issued and applications) on protein biomarkers and molecular diagnostics.

(Click on titles to view the details)

1. Gene expression markers for the diagnosis of Parkinson’s disease.
2. Epigenetic biomarker for the detection of early-onset colorectal cancer.
3. Molecular biomarker for diagnosing drug eruption risk induced by an antiepileptic drug.
4. Placenta-derived exosomal miRNA biomarkers for the diagnosis of preterm birth.
5. Circulating exosomal miRNA biomarkers for the diagnosis of non-small cell lung cancer (NSCLC).
6. Gastrointestinal microbiota as a biomarker for the diagnosis of irritable bowel syndrome (IBD).
7. Blood plasma biomarker panel for the diagnosis of Alzheimer’s disease.
8. Circulating exosomal miRNA biomarkers for the diagnosis of ovarian cancer.
9. Serum biomarker for the diagnosis of non-alcoholic fatty liver disease (NAFLD).
10. Molecular marker for the diagnosis of fibroadenoma.
11. Serum biomarkers for the diagnosis of cardiomyopathies and myocarditis.
12. Biomarker for identifying asymptomatic carrier of liver diseases.
13. Biomarker for the diagnosis of autoimmune chronic urticaria.
14. Mass spectrometry based mitochondrial DNA analysis for bioagents detection and rapid forensic analysis.
15. Diagnosing intestinal roundworm infection in dogs and cats.
16. Diagnosing cat scratch disease caused by Bartonella henselae infection.
17. Serum protein biomarker for monitor a breast cancer patient’s response to glutamine supplementation.
18. Diagnosis of colon cancer by electrochemical methods.
19. Plasma biomarkers for the diagnosis of autism.
20. Mass spectrometry methods for the diagnosis of congenital adrenal hyperplasia (CAH).
21. Adipose triglyceride lipase (ATGL) for the diagnosis of cachexia.
22. PI3K activity for the diagnosis of Fragile X syndrome (FXS).
23. Circulating N-terminal proneurotensin for the diagnosis of Crohn’s Disease or colitis ulcerosa.
24. Diagnostic and prognostic biomarkers of renal injuries and renal failure.
25. Biomarkers for differential diagnosis of pancreatic lesions.
26. Treatment of androgenetic skin disorders based on patient’s genetic information.
27. Biomarkers for the diagnosis of 22q11 deletion syndrome (DiGeorge syndrome).

Related blogs:
How to Identify Clinically Successful Biomarkers?

Strategies for Rational and Personalized Cancer Biomarker Discovery

Related tools:
Comprehensive cancer biomarker database with companion diagnostics pathway

This scientific blog critically analyzes potential complexities associated with current biomarker discovery approaches. According to the scientific arguments that have been put forward in this blog, thousands of biomarkers that are currently being reported may not be true biomarkers of the target disease, rather it may be a complex mixture of biomarkers, which may include target disease specific biomarker as well as biomarkers or biomolecules associated with other diseases, infections, gender, race/ethnic backgrounds, geographic-environmental factors, psychiatric condition/diseases and nutritional factors. Based on our analysis, we believe that an ideal biomarker discovery platform, which can lead to the development of reliable and robust diagnostics assays, should be developed by integrating comprehensive understanding of patients’ phenotypic, genetic and socio-environmental characteristics along with biological and functional relevance of all biomolecules that may be potentially identified and called as biomarkers. Several innovative strategies for developing rational and personalized biomarker discovery platforms have been suggested in this blog. These strategies include 1) Comprehensive genome-scale analysis based rational genetic biomarker discovery 2) Cell or tissue or organ specific function based rational or targeted biomarker discovery 3) Use of validated tissue/organ specific biomarkers or therapeutic drug targets for identifying non-invasive biomarkers, 4) Epidemiology-driven biomarker discovery for developing personalized diagnostic tools and 5) Integrated bioinformatics approaches for rational biomarker discovery. The relevance of disease prevalence and predictive value in biomarker discovery for personalized medicine, utility of rational or personalized biomarkers in clinical trials and applications of rationally identified biomarkers for diagnostics imaging or theranostics have also been discussed. Read the full blog (click on this title): Strategies for Rational and Personalized Cancer Biomarker Discovery

Related tools:

Comprehensive cancer biomarker database with companion diagnostics pathway

Tumor and Tumor Cell Assays and Protocols

Related blogs:

Cancer Theranostics – Potential Applications of Cancer Biomarker Database

Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs


This scientific blog analyzes potential applications of drug response-efficacy biomarkers for predicting future onset of drug therapy induced life-threatening diseases, such as cardiovascular diseases, infectious diseases and cancer. Enabling applications of drug response-efficacy biomarkers for predicting drug-induced side effects may lead to the development of “smart biomarkers”, which can reduce morbidity and mortality in patients, and can revolutionize personalized medicine approaches. In order to achieve this goal, we proposed a model for the discovery of drug response-efficacy biomarkers and the translational utilization of these biomarkers for personalized therapies. In an exploratory analysis, anti-TNF therapy response markers of rheumatoid arthritis (RA) were analyzed, by intelligent data mining and data analysis, to demonstrate that these biomarkers may be potentially used for predicting the risk in developing cardiovascular diseases (CVDs), like atherosclerosis, in RA patients. Please follow this link to read the blog: http://www.sciclips.com/sciclips/blogArticle.do?id=Potential Use of Drug Response-Efficacy Biomarkers for Predicting Life-Threatening Disease Causing Side Effects of Therapeutic Drugs

Related tools:
1. Comprehensive cancer biomarker database with companion diagnostics pathway
2. Bioprotocols
3. Drug discovery news
4. Biomarker news

Related blogs:

1. Cancer Theranostics – Potential Applications of Cancer Biomarker Database

An open access database of biomarker and drug discovery assays/protocols  for neurodegenerative diseases. The listed protocols are extracted from and linked to patents and journal articles.  The innovative representation of protocols in this database will be a useful  tool for idea/concept generation for developing innovative approaches for Alzheimer’s disease and Parkinson’s disease biomarker and drug discovery research. Please follow this link to see the complete list of protocols: http://www.sciclips.com/sciclips/bio-protocols.do?catName=Neurodegenerative%20disease%20biomarker%20and%20drug%20discovery

Related tools:

1. Bioprotocols
2. Comprehensive cancer biomarker database with companion diagnostics pathway
4. Biomarker news


Comprehensive Cancer Bomarker Database

Sciclips consultancy

Diagnostic & Prognostic Biomarker Database

Bioprotocol database (open access)

Combination therapy database (open access)

Therapeutic drug target database (open access)

Bioinformatics databases (open access)

Stem cell researchers database

A comprehensive database for stem cell researchers, Stem cell research reagents, Stem cell patents, Stem cell grants, Stem cell clinical trials, Stem cell statistics, Stem cell news and Stem cell open innovation ideas. Please visit http://www.sciclips.com/

Sciclips consultancy

Proteomics researchers database

A comprehensive database for proteomics researchers, Proteomics research reagents, Proteomics patents, Proteomics grants, Proteomics clinical trials, Proteomics statistics, Proteomics news and Proteomics open innovation ideas. Please visit http://www.sciclips.com/

Share or sell research reagents prepared in your laboratory

Drug target database (open access)

Pharmacogenomics protocols online

Proteomics and Mass spectrometry (MS) protocols online

Therapeutic drug targets database (open access)

Drug discovery, Biopharmaceuticals, HTS assays protocols online

Protein display/Protein engineering/Directed evolution protocols online

Molecular biology and Cell biology protocols online

siRNA protocols miRNA protocols online

Video protocols

Cell culture video protocols, Cytotoxicity assay video protocols, Stem cell video protocols, Molecular biology video protocols http://www.sciclips.com/sciclips/video-protocols.do

Sciclips consultancy

Sciclips

Bioprotocols online (open access)

Combination therapy database (open access)

Therapeutic drug targets database (open access)

Bioinformatics databases (open access)

HTS assay protocols online (open access)