Posts Tagged ‘age-related macular degeneration drug target’
Following are the highlights of recent US patent applications on drug discovery. Details of each patent application with link to respective patents are available in the website.
Cancer
1. Protein kinase CK2 inhibitors for the treatment of cancer
2. Macrophage-stimulating protein receptor (MSP-R or RON) as a drug target for the treatment of cancer
3. Anti-K63-linked polyubiquitin monoclonal antibodies for the treatment of cancer, muscular, immune/inflammatory and neurological disorders
4. Oligonucleotide based drugs for the treatment of B-cell leukemias
5. Next-generation photosensitive medical agent that can simultaneously diagnose cancer and carry out photodynamic therapy (PDT)
6. Combination therapy for melanoma
7. MicroRNAs as therapeutic drugs for the treatment of sarcoma
8. Dual targeting antibodies of VEGFR-2 and Tie-2 receptors for treating cancer
9. A novel chlorin e6-folic acid conjugate for photodynamic therapy of malignant and solid tumors
10. Autotaxin inhibitors for the treatment of cancer
11. MicroRNA (miRNA) as therapeutic drugs for treating cancer
12. Anti-VCAM1-tTF coaguligand for treating cancer
13. Anti-phoshatidylserine antibody-docetaxel combination therapy for the treatment of cancer
14. Targeted cancer therapy using miR-21 promoter driven expression of anti-cancer agents
15. miRNA-184 as therapeutic drug for treating squamous cell carcinoma
Anti-aging
1. Extending lifespan in humans by altering the expression of stress activating proteins
2. Improving wrinkles or preventing aging using panduratin derivatives or Kaempferia pandurata extract
Neurodegenerative and Neuropsychiatric diseases
1. Advanced glycation end products (AGE) as a therapeutic drug target for treating schizophrenia
2. Compounds that relieve axonal blockages for the treatment of neuropathies and neurodegenerative diseases
3. PDE10A enzyme inhibitors for treating neurodegenerative and psychiatric disorders
Viral, Metabolic and Autoimmune diseases
1. MCP-1 derived oligopeptides for the treatment of HIV infection
2. Monoclonal antibodies for treating Hendra virus and Nipah virus infections
3. A novel dengue vaccine
4. Stearoyl-CoA desaturase inhibitors for treating cardiovascular disease, cancer, diabetes, obesity and metabolic syndromes
5. Alpha 4 beta 1 integrin selective inhibitors for the treatment of multiple sclerosis
6. Combination therapy for treating type 2 diabetes
7. siRNAs targeting MAP4K4 for treating metabolic disorders
8. Preadipocytes as drug target for treating obesity
9. IdeS protein for treating arthritis
10. Orexin antagonists for treating obesity
Cardiovascular diseases
1. Biological pacemaker (bio-pacemaker)
2. Inhibitors of platelet aggregation for reducing the risk of thrombocytopenia-associated mortality and morbidity
3. NOTCH pathway inhibitors for the treatment of atherosclerosis
4. S1P1/EDGE1 receptor agonists for treating uncontrolled inflammatory disease and to improve vascular functionality
5. T-type calcium channel inhibitors for treating cardiovascular diseases, epilepsy and pain
6. Vanilloid receptor 1 (VR1) antagonists for treating pain
Eye and Respiratory diseases
1. STAT3 inhibitors for treating age related macular degeneration (AMD)
2. Valproic acid microspheres for the treatment of age-related macular degeneration (AMD)
3. ROCK kinase inhibitors for treating glaucoma
4. Antisense oligonucleotides for treating asthma
5. Biphenyl compounds as muscarinic receptor antagonists for treating chronic obstructive pulmonary disease (COPD) and asthma
6. Brain-derived neurotrophic factor (BDNF) as a therapeutic drug target for treating amblyopia
7. Gremlin as a drug target for treating glaucoma
Miscellaneous diseases
1. Alpha-2-delata ligands for treating non-restorative sleep
2. A cell based reporter assay for the detection of uric acid (uric acid sensor)
3. Dopamine reuptake inhibitors for treating hot flush in pre-menopausal women
4. Compounds that enhance both the transcription activity of Runx2 and the expression level of alkaline phosphatase for treating osteroporosis
5. Melatonin receptors as a therapeutic drug target for treating insomnia
6. Method for treating early morning akinesia
7. mGlu5 antagonists for treating neuromuscular dysfunction of the lower urinary tract and gastroesophageal reflux disease (GERD)
8. Anti-SLAM family member 7 (CS1) antibodies for the treatment of SLE, IBD and myeloma
9. A novel class of C5a complement inhibitors
10. Orexin receptor antagonists for treating eating disorders and drinking disorders
11. Phosphodiesterase (PDE 5) as a therapeutic drug target for treating Peyronie’s disease (PD)
12. Bi-specific antibodies for the treatment of allergy
13. Soluble IL-22R/IL-20RB heterodimeric protein for the treatment of psoriasis
14. Phosphorous transport inhibitors for the treatment of hyperphosphatemia
Details: http://www.sciclips.com/sciclips/drug-discovery-news.do
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4. Biomarker news
Recent Drug Discovery Patents
Posted on: September 19, 2011
Highlights of recent US patent applications, excluding cancer patents, published on September 15, 2011:
1. GABA receptor as a drug target for treating a central nervous system (CNS) injury
2. Inositol and trehalose derivatives for treating Alzheimer’s disease and Huntington’s disease
3. CI-994 or dinaline for treating memory/cognition and anxiety disorders
4. HMGB1 as drug a target for treating necrotizing enterocolitis
5. Potassium 2-(1-hydroxypentyl)-benzoate (PHPB) for treating senile dementia
6. Novel cinamic compounds as histone deacetylase (HDAC) inhibitor
7. Antisense oligonucleotide based modulators of nuclear hormone receptors for the treatment of inflammation
8. Antisense oligonucleotide targeting PCSK9 for the treatment of hypercholesterolemia
9. MicroRNAs as drug target for the treatment of anorexia
10. MicroRNAs associated with PEPCK-c mRNA expression as a drug target for the treatment of diabetes
11. Modulators of peroxisome proliferator activated receptor gamma (PPARgamma) for the treatment of autosomal dominant polycystic kidney disease
12. Prostacyclin (PGI2) receptor as a drug target for the treatment of pulmonary arterial hypertension (PAH)
13. Therapeutic imprinting for the treatment of psychiatric disorders
14. Azaisoquinolinone derivatives as potent NK3 antagonists for the treatment of psychosis
15. Treating seizures and epilepsy by administering huperzine directly to the central nervous system (CNS) tissue
16. Frizzled 2 (FZD2) as a drug target for the treatment of treatment of alopecia
17. Orally administered small molecule c-Mpl agonist for the treatment of thrombocytopenia
18. Alpha adrenergic receptor agonists for treating acute erythema
19. Alpha adrenergic receptor agonists for reducing post-surgical bleeding
20. A novel therapeutic agent for treating age-related macular degeneration or retinitis pigmentosa
21. Hyaluronic acid tetrasaccharide for the treatment of ulcer or hepatopathy
22. Treating various human diseases by activating mitochondria using chitooligosaccharide
23. Glycosilated long pentraxin 3 (PTX3) for treating influenza virus and respiratory syncytial virus infections
24. Protease-resistant mutants of stromal cell derived factor-1 (SDF-1) for treating tissue damage
25. Human chorionic gonadotropin (hCG) for the treatment of mood disorders and alcoholism
26. Cellobiose compounds from herbal extracts for cancer therapy
Details:
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